Question · asked by 1 review
Epidermal growth factor (EGF), oral spray vs placebo: Oral mucositis (moderate to severe)
- Population
- Adults with cancer receiving treatment
- Intervention
- Epidermal growth factor (EGF), oral spray
- Comparison
- placebo
- Outcome
- Oral mucositis (moderate to severe)
Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (moderate to severe) compared with placebo; GRADE not reported.
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Epidermal growth factor (EGF), oral spray vs Placebo Oral mucositis (moderate to severe) · Adults with cancer receiving treatment · Chemoradiotherapy to the head and neck Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (moderate to severe) compared with placebo; GRADE not reported. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and… (2017) · Cochrane All outcomes | RR 1.06 [0.78, 1.43] | 1 study · 136 participants | GRADE not reported |
Epidermal growth factor (EGF), oral spray vs Placebo Oral mucositis (moderate to severe) · Adults with cancer receiving treatment · Radiotherapy to the head and neck Epidermal growth factor (EGF), oral spray led to lower oral mucositis (moderate to severe) compared with placebo; GRADE not reported. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and… (2017) · Cochrane All outcomes | RR 0.67 [0.45, 0.99] | 1 study · 103 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes | 2017-05 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.