Lactobacillus spp. salivary/plaque counts (cariogenic microbiota) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
A meta-analysis found no significant difference in mean Lactobacillus spp. levels between children with and without CLP, with high heterogeneity; the evidence is ungraded.
1 finding from 1 review
Streptococcus mutans count · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
A meta-analysis of 2 studies found no difference in mean Streptococcus mutans levels between children with and without CLP, with very high heterogeneity; the evidence is ungraded.
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, presence of the third molar increases odds of spontaneous space closure (OR 2.28; low certainty).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the maxilla, spontaneous space closure occurred in about 85% of cases (9 studies; prevalence not GRADE-rated).
3 findings from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
Spontaneous space closure is much more likely in the maxilla than the mandible (OR 7.77; low certainty).
1 finding from 1 review
Intervention not reported
Spontaneous space closure
The intervention led to higher spontaneous space closure; GRADE not reported.
1 finding from 1 review
OR 42.0
1 study
GRADE not reported
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at 11-12 vs 8-10 years showed no significant difference in one analysis (OR 0.82; not GRADE-rated).
2 findings from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
One study found mandibular Nolla stage 6-7 associated with better space closure (OR 55.1; single study; not GRADE-rated).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, mean patient age was not significantly associated with space closure odds (OR 0.59 per year; not GRADE-rated).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, distal inclination of the second molar vs upright was not significantly associated with space closure (OR 1.18; not GRADE-rated).
1 finding from 1 review
Midline deviation of the mandibular arch · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
One study found midline deviation more likely after unilateral than bilateral extraction (OR 11.6; single study; not GRADE-rated).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, Demirjian stage F-G vs D-E was not significantly associated with space closure (OR 0.68; not GRADE-rated).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, Demirjian stage A-D vs G-H was not significantly associated with space closure (OR 2.75; not GRADE-rated).
1 finding from 1 review
Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the second premolar was rotated in about 60% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, sex was not significantly associated with space closure (OR 1.38; not GRADE-rated).
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar)
In the maxilla, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 4.78; low certainty).
1 finding from 1 review
Intervention not reported
Spontaneous space closure
1 finding from 1 review
OR >100.00
1 study
GRADE not reported
Lactobacillus spp. mean levels/counts · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
No significant difference in Lactobacillus spp. presence was reported; GRADE was not reported.
1 finding from 1 review
Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction
In the maxilla, M2 Demirjian stages F-G were not associated with a statistically significant difference in space closure odds.
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, Demirjian stage E-F vs G-H was not significantly associated with space closure (OR 4.44; not GRADE-rated).
1 finding from 1 review