Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

172 questions · 179 findings · 40 reviews · Musculoskeletal

No studies found 21 · 11.7%GRADE not reported 7 · 3.9%Very low 24 · 13.4%Low 68 · 38%Moderate 45 · 25.1%High 14 · 7.8%

Autologous myeloablative selective HSCT vs cyclophosphamide

Skin thickness – mRSS Scale 0–51 in which a higher number is worse skin thickening · people with systemic sclerosis

Autologous myeloablative selective HSCT probably leads to higher skin thickness – mRSS Scale 0–51 in which a higher number is worse… compared with cyclophosphamide (moderate certainty).

1 finding from 1 review

Belimumab 10 mg/kg vs placebo

Reduction of at least 4 points in SELENA‐SLEDAI at 52 weeks SELENA‐SLEDAI score, a validated marker of SLE disease activity (range 0 to 105; higher score = worse disease activity) · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg leads to higher reduction of at least 4 points in SELENA‐SLEDAI at 52 weeks… compared with placebo (high certainty).

1 finding from 1 review

Intervention not reported

Pain Scale: VAS (0 to 10), pain subscale of Functional Status Index (0 to 10) Higher score indicates greater pain levels · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Exercise vs no exercise

Hand function ‐ short term (less than 3 months) Grip function test scale of 0 to 80 points (higher score indicates better grip function) · rheumatoid arthritis of the hand
1 finding from 1 review

Exercise vs no exercise

Hand function ‐ long term (12 months and beyond) Overall hand function subscale of the Michigan Hand Questionnaire, 0 to 100 (higher scores mean better hand function) · rheumatoid arthritis of the hand
2 findings from 1 review