Findings

What do systematic reviews say?

80 questions · 82 findings · 10 reviews

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No studies found 9 · 11%GRADE not reported 7 · 8.5%Very low 33 · 40.2%Low 28 · 34.1%Moderate 5 · 6.1%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.24 [0.81, 1.9]
9 studies · 855 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.75, 1.34]
6 studies · 581 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 673 participants
Low

Fish oil vs placebo

Graft thrombosis (up to 12 months) · people with ESRD receiving haemodialysis through an arteriovenous graft

Fish oil showed no clear difference in graft thrombosis (up to 12 months) compared with placebo (low certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.24 [0.03, 1.95]
2 studies · 220 participants
Low

Fish oil vs placebo

Length of hospital stay · people with ESRD receiving haemodialysis through an arteriovenous graft

The review found no eligible studies for this question.

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fish oil vs placebo

Complications (up to 12 months) · people with ESRD receiving haemodialysis through an arteriovenous graft

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 196 participants
Moderate

Fish oil vs placebo

Radiological or surgical intervention (up to 12 months) · people with ESRD receiving haemodialysis through an arteriovenous graft

Fish oil showed no clear difference in radiological or surgical intervention (up to 12 months) compared with placebo (moderate certainty).

1 finding from 1 review

Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts 2021 · Cochrane Headline outcomes only
OR 0.64 [0.36, 1.12]
1 study · 196 participants
Moderate

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

Visual field sensitivity (visual field) · retinitis pigmentosa

1 finding from 1 review

Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 881 participants
Very low

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

Visual acuitychange in logMAR visual acuity, may be reported as ETDRS · retinitis pigmentosa

It is very uncertain whether vitamin A and fish oils (docosahexaenoic acid) changes visual acuitychange in logMAR visual acuity, may be reported as ETDRS compared with placebo, vitamins (including vitamin A), or no therapy (very low certainty).

1 finding from 1 review

Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 881 participants
Very low

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

Electroretinography (ERG) · retinitis pigmentosa

1 finding from 1 review

Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 881 participants
Very low

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

Optical coherence tomography (OCT) · retinitis pigmentosa

1 finding from 1 review

Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Very low

Vitamin A and fish oils (docosahexaenoic acid) vs placebo, vitamins, or no treatment

Adverse effects: as reported by studies · retinitis pigmentosa

1 finding from 1 review

Vitamin A and fish oils for preventing the progression of retinitis pigmentosa 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 944 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.28 [0.69, 2.35]
5 studies · 399 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 261 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 374 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.02 [0.7, 1.5]
4 studies · 341 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.92 [0.61, 1.39]
5 studies · 373 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.43 [0.06, 2.85]
3 studies · 256 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Parenteral nutrition‐associated liver disease/cholestasis · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in parenteral nutrition‐associated liver disease/cholestasis compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.8 [0.29, 2.16]
4 studies · 341 participants
Low