Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

80 questions · 82 findings · 10 reviews

No studies found 9 · 11%GRADE not reported 7 · 8.5%Very low 33 · 40.2%Low 28 · 34.1%Moderate 5 · 6.1%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE vs non‐fish oil LE (combined subgroups) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition: low and unclear risk of bias studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition: low and unclear risk of bias… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition): combined subgroups (all studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (any definition): combined subgroups (all studies)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed term and late preterm infants with surgical conditions

It is very uncertain whether fish oil LE changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/cholestasis (conjugated bilirubin less than2 mg/dL) Pure F‐LE vs S‐LE · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes resolution of PNALD/cholestasis (conjugated bilirubin less than2… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Any sepsis (clinical and/or culture positive) · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes any sepsis (clinical or culture positive (or both)) MOFS‐LE vs S‐LE… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review