Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,181 questions · 1,197 findings · 144 reviews

No studies found 196 · 16.4%GRADE not reported 213 · 17.8%Very low 274 · 22.9%Low 296 · 24.7%Moderate 171 · 14.3%High 47 · 3.9%

Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?

Adverse effects: at least one serious adverse event

Are disease‐modifying drugs for a first attack suggestive of… showed no clear difference in occurrence of at least one serious adverse event Proportion of… compared with placebo? (low certainty).

1 finding from 1 review

Mental health treatment court with assertive case management model vs treatment

Conviction for a new crime · drug‐using offenders with co‐occurring mental health problems

Mental health treatment court with assertive case management model showed no clear difference in conviction for a new crime compared with treatment (low certainty).

1 finding from 1 review

Mental health treatment court with assertive case management model vs treatment

Re‐incarceration to jail · drug‐using offenders with co‐occurring mental health problems

Mental health treatment court with assertive case management model showed no clear difference in re‐incarceration to jail compared with treatment (low certainty).

1 finding from 1 review

Certolizumab pegol vs placebo

Any severe adverse event during maintenance treatment · people with Crohn's disease who responded to CZP remission‐induction treatment

Certolizumab pegol showed no clear difference in serious adverse events during remission maintenance treatment(1 RCT,… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Total studies: 282 RCTs Total participants: 50,812 Number of treatments: 65 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review

Intervention not reported

Total studies: 117 RCTs Total participants: 21,440 Number of treatments: 44 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review

Intervention not reported

Total studies: 64 RCTs Total participants: 10,724 Number of treatments: 30 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review

Intervention not reported

Total studies: 43 RCTs Total participants: 11,481 Number of treatments: 23 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review

Intervention not reported

Total studies: 32 RCTs Total participants: 4369 Number of treatments: 10 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review

Intervention not reported

Total studies: 25 RCTs Total participants: 5067 Number of treatments: 18 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review

Intervention not reported

Total studies: 21 RCTs Total participants: 3634 Number of treatments: 12 Geometry of the network** · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review