Transfusion of blood products
Starches probably leads to higher transfusion of blood products compared with crystalloid (moderate certainty).
1 finding from 1 review
Renal replacement therapy
Starches probably leads to higher renal replacement therapy compared with crystalloid (moderate certainty).
1 finding from 1 review
Adverse events
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
All‐cause mortality (at end of
Dextrans showed no clear difference in all‐cause mortality (at end of compared with crystalloid (moderate certainty).
1 finding from 1 review
All‐cause mortality (within 90 days and within 30 days)
Dextrans showed no clear difference in all‐cause mortality (within 90 days and within 30 days) compared with crystalloid (moderate certainty).
1 finding from 1 review
Transfusion of blood products
It is very uncertain whether dextrans changes transfusion of blood products compared with crystalloid (very low certainty).
1 finding from 1 review
Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery
Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).
1 finding from 1 review
Organ system failure ‐ renal insufficiency requiring support · adults receiving intravenous fluids whilst undergoing any form of surgery
Buffered showed no clear difference in organ system failure ‐ renal insufficiency requiring support compared with non‐buffered crystalloid intravenous fluid (low certainty).
1 finding from 1 review
Plasma pH ‐ postoperative pH · adults receiving intravenous fluids whilst undergoing any form of surgery
1 finding from 1 review
Postoperative chloride mmol/L · adults receiving intravenous fluids whilst undergoing any form of surgery
1 finding from 1 review
Maternal hypotension requiring intervention · women having spinal anaesthesia for caesarean section
It is very uncertain whether colloid changes maternal hypotension requiring intervention compared with crystalloid (very low certainty).
1 finding from 1 review
Maternal hypertension requiring intervention · women having spinal anaesthesia for caesarean section
It is very uncertain whether colloid changes maternal hypertension requiring intervention compared with crystalloid (very low certainty).
1 finding from 1 review
Maternal bradycardia requiring intervention · women having spinal anaesthesia for caesarean section
It is very uncertain whether colloid changes maternal bradycardia requiring intervention compared with crystalloid (very low certainty).
1 finding from 1 review
Maternal nausea and/or vomiting · women having spinal anaesthesia for caesarean section
It is very uncertain whether colloid changes maternal nausea and/or vomiting compared with crystalloid (very low certainty).
1 finding from 1 review
Neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 · women having spinal anaesthesia for caesarean section
It is very uncertain whether colloid changes neonatal acidosis as defined by cord or neonatal blood with a pH < 7.2 compared with crystalloid (very low certainty).
1 finding from 1 review
Neonatal Apgar score < 8 at 5 minutes · women having spinal anaesthesia for caesarean section
It is very uncertain whether colloid changes neonatal Apgar score < 8 at 5 minutes compared with crystalloid (very low certainty).
1 finding from 1 review
Admission to neonatal intensive care unit · women having spinal anaesthesia for caesarean section
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality up to 30 days № of participants: 72 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures
It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes all‐cause mortality up to 30 days № of participants: 72 (1 RCT) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).
1 finding from 1 review
RR 0.38 [0.13, 1.1]
Studies not reported
Very low
Major bleeding · patients undergoing non‐cardiac surgery/invasive procedures
It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes major bleeding within 24 hours № of participants: 148 (2 RCTs) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).
1 finding from 1 review
RR 0.33
Studies not reported
Very low
Number of transfusions per participant within 7 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures
1 finding from 1 review
no estimate extracted
Studies not reported
Very low