Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 66 findings · 13 reviews

No studies found 8 · 12.1%GRADE not reported 4 · 6.1%Very low 14 · 21.2%Low 29 · 43.9%Moderate 7 · 10.6%High 4 · 6.1%

Combined steroid and antibiotic therapy vs antibiotics alone

Complete resolution of endophthalmitis at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

It is very uncertain whether combined steroid and antibiotic therapy changes complete resolution of endophthalmitis at 3 months' compared with antibiotics alone (very low certainty).

1 finding from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Visual acuity · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy may leads to higher visual acuity 6/6 to 6/18 at 3 months' compared with antibiotics alone (low certainty).

2 findings from 1 review

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Hard tissue probing at surgical re-entry (bone gain) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Attachment change · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher change in clinical attachment level (attachment gain) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Change in probing pocket depth (PPD) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher change in probing depth (probing depth reduction) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Change in gingival recession (REC) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to lower change in gingival recession compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of PEa (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of PEa (early postoperative period) compared with IPC alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of DVTc (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

IPC plus pharmacological prophylaxis may leads to lower incidence of DVTc (early postoperative period) compared with IPC alone (low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of bleedingd (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of bleedingd (early postoperative period) compared with IPC alone (very low certainty).

1 finding from 1 review

IPC plus pharmacological prophylaxis vs IPC alone

Incidence of major bleedingf (early postoperative period) · people undergoing surgery or at risk of developing VTE because of surgery, trauma or ICU stay

It is very uncertain whether IPC plus pharmacological prophylaxis changes incidence of major bleedingf (early postoperative period) compared with IPC alone (very low certainty).

1 finding from 1 review