Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

136 questions · 139 findings · 26 reviews

No studies found 12 · 8.6%GRADE not reported 25 · 18%Very low 36 · 25.9%Low 43 · 30.9%Moderate 19 · 13.7%High 4 · 2.9%

Intervention not reported

Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Death · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Tuberculosis · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in tuberculosis compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Disease progression measured by opportunistic disease Opportunistic disease events · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant HIV Transmission or Death at 6 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora: AZT/3TC/LPV‐r showed no clear difference in infant HIV Transmission or Death at 6 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at Birth · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission at Birth compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at 6 Weeks · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission at 6 Weeks compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at 6 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

Kesho Bora continued: AZT/3TC/LPV‐r may leads to lower mother to Child Transmission at 6 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Mother to Child Transmission at 12 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

It is very uncertain whether kesho Bora continued: AZT/3TC/LPV‐r changes mother to Child Transmission at 12 Months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Women With Any Grade 3/4 Severe Adverse Event (Laboratory Only) · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

It is very uncertain whether mma Bana: AZT/3TC/LPV‐r changes women With Any Grade 3/4 Severe Adverse Event (Laboratory Only) compared with AZT/3TC/ABC (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Women With Any Severe Adverse Events Requiring Treatment Modification · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

It is very uncertain whether mma Bana: AZT/3TC/LPV‐r changes women With Any Severe Adverse Events Requiring Treatment Modification compared with AZT/3TC/ABC (very low certainty).

1 finding from 1 review

Kesho Bora: AZT/3TC/LPV‐r vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV Transmission or Death at 12 Months · HIV‐infected Pregnant Women With CD4 Counts 200‐500 Cells/mm3

It is very uncertain whether kesho Bora: AZT/3TC/LPV‐r changes infant HIV Transmission or Death at 12 months compared with short‐Course AZT (intrapartum AZT/3TC/sd‐NVP) (very low certainty).

1 finding from 1 review

Mma Bana: AZT/3TC/LPV‐r vs AZT/3TC/ABC

Mother to Child Transmission In Utero Positive HIV DNA PCR Within 96 Hours · HIV‐Infected Pregnant Women With CD4 Counts >200 cells/mm3

Mma Bana continued: AZT/3TC/LPV‐r showed no clear difference in mother to Child Transmission In Utero Positive HIV DNA PCR Within 96… compared with AZT/3TC/ABC (low certainty).

1 finding from 1 review