Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

339 questions · 346 findings · 42 reviews · Headline outcomes only

No studies found 74 · 21.4%GRADE not reported 8 · 2.3%Very low 72 · 20.8%Low 107 · 30.9%Moderate 68 · 19.7%High 17 · 4.9%

Vitamin D plus calcium vs placebo or control

Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to higher persons with renal disease (calculi or insufficiency) ‐ Vitamin D… compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D plus calcium vs placebo or control

Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Death or dependency at end of · people with acute ischemic stroke

Calcium antagonists showed no clear difference in death or dependency at end of compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Death at the end of treatment · people with acute ischemic stroke

Calcium antagonists showed no clear difference in death at the end of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Recurrence of stroke at the end of · people with acute ischemic stroke

Calcium antagonists showed no clear difference in recurrence of stroke at the end of compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Adverse events during treatment period · people with acute ischemic stroke

Calcium antagonists showed no clear difference in adverse events during treatment period compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists vs placebo

Systolic blood pressure · people with acute ischemic stroke

Calcium antagonists showed no clear difference in mean systolic blood pressure during or at end of treatment compared with placebo (low certainty).

1 finding from 1 review