Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

72 questions · 72 findings · 12 reviews · Anaesthesia

No studies found 1 · 1.4%GRADE not reported 6 · 8.3%Very low 24 · 33.3%Low 18 · 25%Moderate 20 · 27.8%High 3 · 4.2%

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

Intervention not reported

Postoperative delirium (POD) within 7 days (As assessed by any method such as the Mini‐Mental State Examination (MMSE) and Confusion Assessment Method (CAM) in the first week after operation) · adults aged 18 years or over undergoing general anaesthesia for non‐cardiac or non‐neurosurgical elective operations

The intervention probably leads to lower postoperative delirium (POD) within 7 days (As assessed by any… (moderate certainty).

1 finding from 1 review

Intervention not reported

Postoperative cognitive dysfunction (POCD) (As determined by any method of assessing POCD including a battery of neuropsychological tests according to the criteria described by the International Study of Postoperative Cognitive Dysfunction (ISPOCD)) · adults aged 18 years or over undergoing general anaesthesia for non‐cardiac or non‐neurosurgical elective operations

The intervention showed no clear difference in postoperative cognitive dysfunction (POCD) (As determined by any… (moderate certainty).

1 finding from 1 review

Intervention not reported

Any postoperative complication · adults aged 18 years or over undergoing general anaesthesia for non‐cardiac or non‐neurosurgical elective operations

The intervention probably leads to lower any postoperative complication (moderate certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Inadequate oxygenation (SaO₂ < 90% on peripheral oxygen saturation) · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

It is very uncertain whether proSeal changes inadequate oxygenation (SaO₂ < 90% on peripheral oxygen saturation) compared with classic laryngeal mask airway (LMA) (very low certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Sore throat · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

ProSeal showed no clear difference in sore throat compared with classic laryngeal mask airway (LMA) (low certainty).

1 finding from 1 review

ProSeal vs Classic laryngeal mask airway (LMA)

Regurgitation · adult patients (18 years of age and older) for positive pressure ventilation undergoing elective surgery

ProSeal showed no clear difference in regurgitation compared with classic laryngeal mask airway (LMA) (low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with no treatment (very low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

Acute myocardial infarction · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes acute myocardial infarction compared with no treatment (very low certainty).

1 finding from 1 review

Nitroglycerin vs no treatment

Cardiac ischaemia indicated by ECG · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes cardiac ischaemia indicated by ECG compared with no treatment (very low certainty).

1 finding from 1 review