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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

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No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Co-presence of Veillonella spp. with Streptococcus mutans vs Streptococcus mutans acidogenesis without Veillonella spp. modulation (conceptual)

Streptococcus mutans acid (lactic acid) production and cariogenic potential · Oral biofilm of children/individuals at risk of dental caries

The review concludes that Veillonella spp. may modulate (often inhibit) S. mutans acid production and compete for lactate substrate, potentially reducing cariogenesis, but the evidence is narrative and ungraded.

1 finding from 1 review

Replacement of the defective restoration vs Repair of the defective restoration

Composite: Preference for replacement over repair - Scenario 6: superficial discoloration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…

For a defective composite restoration with superficial discoloration, surveyed dentists most often preferred repair over replacement (pooled RR 0.28; p < 0.001); ungraded.

1 finding from 1 review

Country-level dental caries prevalence (Global Burden of Disease) vs Low vs high dental caries prevalence

Oral health-related quality of life · people aged 60 years and older living in the community

Lower country-level dental caries prevalence was associated with better OHRQoL (low-prevalence pooled mean 81.5, 95% CI 76.5 to 86.6, higher than high-prevalence countries); statistically significant (ungraded).

1 finding from 1 review

Partial pulpotomy vs Full (complete) pulpotomy

Patient- and clinical-reported outcomes (tooth survival, clinical/radiographic success, pain) · Permanent teeth with deep caries and reversible pulpitis (non-spontaneous pain)

No studies compared partial versus full pulpotomy in permanent teeth with reversible pulpitis (non-spontaneous pain), so no evidence is available.

1 finding from 1 review

Anorexia nervosa (as exposure; diagnosed by DSM-III/III-R/IV/V) vs Healthy controls

Gingival (marginal) recession · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population

Gingival (marginal) recession was significantly higher in anorexia nervosa patients than controls in both reporting studies, but was not pooled or graded (ungraded).

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella spp. and Streptococcus mutans interaction · Children under 6 years with severe early childhood caries and caries-free controls

The study reported a possible role for Veillonella spp. in supporting cariogenic species, without a quantitative effect estimate.

1 finding from 1 review

HAART (highly active antiretroviral therapy, >=3 drugs) vs HIV-positive not receiving HAART (standard ART or HAART-naive)

Caries in primary teeth: dmft (3 years) · Children and adolescents (<18 years) living with HIV (CLWH)

Among HIV+ children, HAART versus no HAART showed no significant difference in the dmft index in case-control studies (MD 0.66, 95% CI -0.26 to 1.58; ungraded).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs HIV-negative individuals

Dental caries (by severity) · Children and adolescents (<18 years) living with HIV (CLWH)

In cross-sectional studies, HIV+ children on ART had a significantly higher DMFS index than HIV-negative peers (MD 2.00, 95% CI 1.54 to 2.46; not separately GRADE-rated).

2 findings from 1 review

Anorexia nervosa (as exposure; diagnosed by DSM-III/III-R/IV/V) vs Healthy controls

Dental erosion · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general community-dwelling population

Dental erosion was more prevalent in anorexia nervosa patients than controls (low erosive-wear severity), but was not pooled or graded (ungraded).

1 finding from 1 review

Flavonoids (e.g., quercetin, proanthocyanidin) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Flavonoids vs Calcium showed no significant difference in 24 h bond strength (MD 5.728, 95% CI -2.442 to 13.897; Moderate certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Flavonoids (e.g., quercetin, proanthocyanidin)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp showed 7.520 MPa lower 24 h bond strength than Flavonoids (MD -7.520, 95% CI -14.758 to -0.281; Moderate certainty).

1 finding from 1 review