Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,256 questions · 2,339 findings · 262 reviews

No studies found 555 · 23.7%GRADE not reported 398 · 17%Very low 572 · 24.5%Low 476 · 20.4%Moderate 240 · 10.3%High 98 · 4.2%

Multinutrient supplements (oral) vs control

Participants with complications (e.g. pressure sore, chest infection) at end of study · Older people undergoing hip fracture aftercare

Multinutrient supplements (oral) may leads to lower participants with complications (e.g. pressure sore, chest… compared with control (low certainty).

1 finding from 1 review

Double vs single‐injection technique

Primary anaesthesia failure (incomplete sensory block) · Adult patients undergoing hand, wrist or forearm surgery

Double leads to lower primary anaesthesia failure (incomplete sensory block) compared with single‐injection technique (high certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Adverse events: General ‐ serious Unclear how these events were reported · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes adverse events: General ‐ serious Unclear how these events were… compared with ORAL ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

Intervention not reported

Pain Acroparaesthesia and Fabry crises · Anderson‐Fabry disease

The review found no eligible studies for this question.

1 finding from 1 review

Pyridoxine vs placebo

Adverse effects: headache · Pregnant women with hyperemesis gravidarum

Pyridoxine showed no clear difference in interventions side effects: headaches compared with placebo (low certainty).

1 finding from 1 review

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Need for anaesthesia · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) led to lower need for anaesthesia compared with conventional mechanical caries removal (standard drill; handpiece…; GRADE not reported.

2 findings from 1 review

Intervention not reported

Retention on treatment Duration of retention on treatment was not reported in these studies. The retention on treatment in this analysis is assessed by the number of withdrawals in the intervention and placebo groups The results show a trend in fa... · people with epilepsy and intellectual disability

The intervention showed no clear difference in retention on treatment Duration of retention on treatment was not… (moderate certainty).

1 finding from 1 review