Cochrane · systematic review · CD005399
Pharmacological interventions for epilepsy in people with intellectual disabilities
Jackson, CF, Makin, SM, Marson, AG, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 60%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with epilepsy and intellectual disability
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention on treatment Duration of retention on treatment was not reported in these studies. The retention on treatment in this analysis is assessed by the number of withdrawals in the intervention and placebo groups The results show a trend in fa... | RR 1.43 [0.76, 2.69] | 3 studies · 310 participants | Moderate |
Seizure freedom 1 study reported the incidence of seizure frequency in the intervention and placebo group The results show a trend in favour of the AED group | RR 2.92 [0.32, 26.77] | 1 study · 73 participants | Low |
Responder rate (≥ 50% reduction in overall seizure frequency) | RR 2.58 [1.6, 4.14] | 3 studies · 382 participants | Low |
Responder rate (≥ 50% reduction in rate of drop seizures) | RR 6.04 [0.27, 133.89] | 2 studies · 313 participants | Low |
Adverse events 4 studies reported the frequency of self reported adverse events in the AED and placebo groups The results show a trend in favour of the placebo groups | RR 1.13 [0.95, 1.35] | 4 studies · 527 participants | Moderate |