Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Proportion of participants experiencing postoperative complicationsover 24 months (medium‐term) · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in proportion of participants experiencing postoperative… compared with phacoemulsification alone (moderate certainty).

1 finding from 1 review

Laparoscopic pyloromyotomy vs open pyloromyotomy

Postoperative wound infection or abscess formation · infants (< 1 year of age) with hypertrophic pyloric stenosis

It is very uncertain whether laparoscopic pyloromyotomy changes postoperative wound infection or abscess formation compared with open pyloromyotomy (very low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo

Wound infection · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

It is very uncertain whether antibiotic prophylaxis changes all wound infections (SSSI + DSSI) compared with placebo (very low certainty).

2 findings from 1 review

Antibiotic prophylaxis vs placebo

DSSI · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

Antibiotic prophylaxis showed no clear difference in DSSI compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo

DSSI ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

Antibiotic prophylaxis showed no clear difference in DSSI ‐ low infection risk environment compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo

DSSI ‐ high infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

Antibiotic prophylaxis showed no clear difference in DSSI ‐ high infection risk environment compared with placebo (low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo

All wound infections (SSSI + DSSI) ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

It is very uncertain whether antibiotic prophylaxis changes all wound infections (SSSI + DSSI) ‐ low infection risk environment compared with placebo (very low certainty).

2 findings from 1 review

Antibiotic prophylaxis vs placebo

All wound infections (SSSI + DSSI) ‐ high infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

It is very uncertain whether antibiotic prophylaxis changes all wound infections (SSSI + DSSI) ‐ high infection risk environment compared with placebo (very low certainty).

2 findings from 1 review

Antibiotic prophylaxis vs placebo

SSSI · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

Antibiotic prophylaxis probably leads to lower SSSI compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo

SSSI ‐ low infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

Antibiotic prophylaxis showed no clear difference in SSSI ‐ low infection risk environment compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis vs placebo

SSSI ‐ high infection risk environment · prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair

It is very uncertain whether antibiotic prophylaxis changes SSSI ‐ high infection risk environment compared with placebo (very low certainty).

1 finding from 1 review

Cataract surgery with Hydrus microstent vs cataract surgery alone

Proportion of participants who were medication‐free (not using eye drops) medium‐term · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

Cataract surgery with Hydrus microstent probably leads to higher proportion of participants who were medication‐free (not using eye… compared with cataract surgery alone (moderate certainty).

1 finding from 1 review