Cochrane · systematic review · CD003769
Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair
Orelio, CC, van Hessen, C, Sanchez-Manuel, FJ, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
ColorectalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 41.7%Low 1 · 8.3%Moderate 6 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotic prophylaxis compared to placebo for prevention of postoperative wound infection in adults undergoing open inguinal or femoral herniorrhaphy surgery
Population: prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral herniorrhaphy hernia repair
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All wound infections (SSSI + DSSI) Antibiotic prophylaxis vs placebo | RR 0.86 [0.56, 1.33] | 5 studies · 1865 participants | Very low Downgraded: risk of bias |
All wound infections (SSSI + DSSI) ‐ low infection risk environment Antibiotic prophylaxis vs placebo | RR 0.63 [0.28, 1.41] | 4 studies · 1302 participants | Very low Downgraded: risk of bias, imprecision |
All wound infections (SSSI + DSSI) ‐ high infection risk environment Antibiotic prophylaxis vs placebo | RR 0.99 [0.58, 1.68] | 1 study · 563 participants | Very low Downgraded: risk of bias, imprecision |
Antibiotic prophylaxis compared to placebo for prevention of postoperative wound infection in adults undergoing open inguinal or femoral hernioplasty surgery
Population: prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernioplasty hernia repair
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All wound infections (SSSI + DSSI) Antibiotic prophylaxis vs placebo | RR 0.61 [0.48, 0.78] | 22 studies · 6443 participants | Moderate Downgraded: risk of bias |
All wound infections (SSSI + DSSI) ‐ low infection risk environment Antibiotic prophylaxis vs placebo | RR 0.71 [0.44, 1.14] | 9 studies · 3100 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
All wound infections (SSSI + DSSI) ‐ high infection risk environment Antibiotic prophylaxis vs placebo | RR 0.58 [0.43, 0.77] | 13 studies · 3343 participants | Very low Downgraded: risk of bias |
SSSI Antibiotic prophylaxis vs placebo | RR 0.6 [0.46, 0.78] | 21 studies · 6263 participants | Moderate Downgraded: risk of bias |
SSSI ‐ low infection risk environment Antibiotic prophylaxis vs placebo | RR 0.71 [0.44, 1.17] | 9 studies · 3100 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
SSSI ‐ high infection risk environment Antibiotic prophylaxis vs placebo | RR 0.56 [0.41, 0.77] | 12 studies · 3163 participants | Very low Downgraded: risk of bias |
DSSI Antibiotic prophylaxis vs placebo | RR 0.65 [0.26, 1.65] | 12 studies · 4185 participants | Moderate Downgraded: risk of bias |
DSSI ‐ low infection risk environment Antibiotic prophylaxis vs placebo | RR 0.67 [0.11, 4.13] | 3 studies · 1488 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
DSSI ‐ high infection risk environment Antibiotic prophylaxis vs placebo | RR 0.64 [0.22, 1.89] | 9 studies · 2697 participants | Low Downgraded: risk of bias |