What do systematic reviews say?

A dose of vitamin D 601 IU or higher vs 600 IU or lower alone or with other nutrients

It is very uncertain whether A dose of vitamin D 601 IU or higher changes low birthweight compared with 600 IU or lower alone or with other nutrients (very low certainty).

• Regimens of vitamin D supplementation for women during pregnancy 2019 · Cochrane Headline outcomes only
  RR 0.9 [0.66, 1.24]
  4 studies · 1550 participants
  Very low

Direct oral anticoagulant secondary prophylaxis vs Low molecular weight heparin secondary prophylaxis

It is very uncertain whether direct oral anticoagulant secondary prophylaxis changes major lower GI bleeding compared with low molecular weight heparin secondary prophylaxis (very low certainty).

• Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer 2018 · Cochrane Headline outcomes only
  RR 1.1 [0.43, 2.8]
  4 studies · 1838 participants
  Very low

Direct oral anticoagulant secondary prophylaxis vs Low molecular weight heparin secondary prophylaxis

Direct oral anticoagulant secondary prophylaxis showed no clear difference in minor lower GI bleeding compared with low molecular weight heparin secondary prophylaxis (low certainty).

• Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer 2018 · Cochrane Headline outcomes only
  RR 1.54 [0.72, 3.27]
  2 studies · 1495 participants
  Low

Low molecular weight heparin vs unfractionated heparin

It is very uncertain whether low molecular weight heparin changes success rate of replantation1 (analysed by participant, compared with unfractionated heparin (very low certainty).

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  RR 0.98 [0.87, 1.1]
  2 studies · 130 participants
  Very low

Low molecular weight heparin vs unfractionated heparin

Low molecular weight heparin showed no clear difference in success rate of replantation1 (analysed by digit, compared with unfractionated heparin (low certainty).

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  RR 0.97 [0.9, 1.04]
  2 studies · 200 participants
  Low

Low molecular weight heparin vs unfractionated heparin

The review found no eligible studies for this question.

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low molecular weight heparin vs unfractionated heparin

The review found no eligible studies for this question.

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low molecular weight heparin vs unfractionated heparin

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ arterial… compared with unfractionated heparin (very low certainty).

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  RR 1.08 [0.16, 7.1]
  1 study · 54 participants
  Very low

Low molecular weight heparin vs unfractionated heparin

It is very uncertain whether low molecular weight heparin changes microvascular insufficiency due to vessel occlusion ‐ venous… compared with unfractionated heparin (very low certainty).

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  RR 0.81 [0.2, 3.27]
  1 study · 54 participants
  Very low

Low molecular weight heparin vs unfractionated heparin

Low molecular weight heparin showed no clear difference in complication and adverse reactions ‐ wound bleeding (analysed by… compared with unfractionated heparin (low certainty).

• Low molecular weight heparin for prevention of microvascular occlusion in digital replantation 2020 · Cochrane Headline outcomes only
  RR 0.53 [0.23, 1.23]
  2 studies · 130 participants
  Low

Slow-release fluoride devices vs Alternative fluoride therapy (topical fluoride: toothpaste, mouthrinse, gel, or varnish)

The review found no eligible studies for this question.

• Slow‐release fluoride devices for the control of dental decay 2018 · Cochrane All outcomes
  We found no studies comparing a slow-release fluoride device versus alternative fluoride therapy
  0 studies
  No studies found

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 352 participants
  High

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 112 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 112 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 103 participants
  Low

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 169 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM)

Low dialysate [Na+] (< 138 mM) showed no clear difference in intradialytic cramps compared with neutral dialysate [Na+] (138 to 140 mM) (low certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.66 [0.92, 2.98]
  4 studies · 11700 participants
  Low

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 89 participants
  Moderate

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

Low dialysate [Na+] (< 138 mM) showed no clear difference in intradialytic hypotension compared with high dialysate [Na+] (> 140 mM) (low certainty).

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  RR 1.71 [0.57, 5.07]
  2 studies · 486 participants
  Low

Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM)

• Low dialysate sodium levels for chronic haemodialysis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 44 participants
  Low