Cochrane · systematic review · CD011204
Low dialysate sodium levels for chronic haemodialysis
Dunlop, JL, Vandal, AC, Marshall, MR · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
20
No studies
1
Included studies
NR
No studies 1 · 4.8%Ungraded 0 · 0%Very low 0 · 0%Low 9 · 42.9%Moderate 9 · 42.9%High 2 · 9.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Low dialysate [Na+] (< 138 mM) versus neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) for chronic haemodialysis
Population: chronic HD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IDWG Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | no estimate extracted | 10 studies · 352 participants | High |
Intradialytic hypotension Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | RR 1.52 [1.14, 2.02] | 7 studies · 12570 participants | Moderate Downgraded: indirectness |
Predialysis MAP Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | no estimate extracted | 4 studies · 156 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Postdialysis MAP Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | no estimate extracted | 4 studies · 150 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Antihypertensive medication Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | no estimate extracted | 2 studies · 103 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Predialysis serum [Na+] Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | no estimate extracted | 7 studies · 258 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Intradialytic cramps Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) or high dialysate [Na+] (> 140 mM) | RR 1.77 [1.15, 2.73] | 6 studies · 12186 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Low dialysate [Na+] (< 138 mM) versus neutral dialysate [Na+] (138 to 140 mM) for chronic haemodialysis
Population: chronic HD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IDWG Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | no estimate extracted | 6 studies · 263 participants | High |
Intradialytic hypotension Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | RR 1.49 [1.09, 2.03] | 5 studies · 12084 participants | Moderate Downgraded: indirectness |
Predialysis MAP Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | no estimate extracted | 2 studies · 112 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Postdialysis MAP Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | no estimate extracted | 2 studies · 112 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Antihypertensive medication Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | no estimate extracted | 2 studies · 103 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Predialysis serum [Na+] Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | no estimate extracted | 3 studies · 169 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Intradialytic cramps Low dialysate [Na+] (< 138 mM) vs neutral dialysate [Na+] (138 to 140 mM) | RR 1.66 [0.92, 2.98] | 4 studies · 11700 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Low dialysate [Na+] (< 138 mM) versus high dialysate [Na+] (> 140 mM) for chronic haemodialysis
Population: chronic HD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
IDWG Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | no estimate extracted | 4 studies · 89 participants | Moderate Downgraded: imprecision |
Intradialytic hypotension Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | RR 1.71 [0.57, 5.07] | 2 studies · 486 participants | Low Downgraded: imprecision, indirectness |
Predialysis MAP Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | no estimate extracted | 2 studies · 44 participants | Low Downgraded: imprecision, indirectness |
Postdialysis MAP Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | no estimate extracted | 2 studies · 38 participants | Low Downgraded: imprecision, indirectness |
Antihypertensive medication Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | no estimate extracted | NR | No studies |
Predialysis serum [Na+] Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | no estimate extracted | 4 studies · 89 participants | Moderate Downgraded: imprecision |
Intradialytic cramps Low dialysate [Na+] (< 138 mM) vs high dialysate [Na+] (> 140 mM) | RR 1.94 [1.54, 2.44] | 2 studies · 486 participants | Low Downgraded: imprecision, indirectness |