Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

662 questions · 720 findings · 164 reviews

No studies found 177 · 24.6%GRADE not reported 126 · 17.5%Very low 144 · 20%Low 139 · 19.3%Moderate 107 · 14.9%High 27 · 3.8%

COMPARISON 1. ARIPIPRAZOLE vs placebo

Requirement for anticholinergics number of participants requiring medication for extrapyramidal side effects · patients with an acute manic or mixed episode

Aripiprazole leads to higher requirement for anticholinergics number of participants requiring… compared with placebo (high certainty).

1 finding from 1 review

Any Psychosocial intervention plus pharm vs pharm standard

Retention in treatment · patients with treatment of opioid dependence

Any Psychosocial intervention plus pharm showed no clear difference in retention in treatment Objective compared with pharm standard (high certainty).

1 finding from 1 review