Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,447 questions · 2,590 findings · 266 reviews

No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Lamotrigine vs lithium

Recurrence of any episodes at one year (active suicidal behavior) · bipolar disorder

It is very uncertain whether lamotrigine changes recurrence of any episodes at one year (active suicidal behavior) compared with lithium (very low certainty).

1 finding from 1 review

Spectacle correction vs no spectacles

Proportion of children without refractive error in the emmetropization range at 3 years · infants or children with hyperopia

It is very uncertain whether spectacle correction changes proportion of children without refractive error in the… compared with no spectacles (very low certainty).

1 finding from 1 review

Intervention not reported

Behavioural predictors of car use Intention to use active transport after obtaining a driving licence. Measured pre‐ and postintervention, and at 8 weeks' · teenagers, aged 17–19 years
1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Mean refractive error expressed as mean spherical equivalent post‐treatment. ‐ 12 months · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism
1 finding from 1 review

Intervention not reported

No active intervention (only maintenance immunosuppression) (1 RCT; 45 participants) · adults undergoing liver transplantation

It is very uncertain whether the intervention changes no active intervention (only maintenance immunosuppression) (1 RCT;… (very low certainty).

1 finding from 1 review

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

Postoperative residual refractive astigmatism of less than 0.50 D · people with astigmatism who are having cataract surgery (phacoemulsification)

Toric intraocular lens (IOL) probably leads to higher postoperative residual refractive astigmatism of less than 0.50 D compared with limbal relaxing incisions (LRIs) (moderate certainty).

1 finding from 1 review

MVA85A vs placebo

Active tuberculosis: confirmed by culture or Xpert® MTB/RIF longest reported · HIV‐positive and ‐negative adults and children

MVA85A showed no clear difference in active tuberculosis: confirmed by culture or Xpert® MTB/RIF longest… compared with placebo (moderate certainty).

1 finding from 1 review

MVA85A vs placebo

Active tuberculosis: started on tuberculosis treatment · HIV‐positive and ‐negative adults and children

MVA85A showed no clear difference in active tuberculosis: started on tuberculosis treatment compared with placebo (moderate certainty).

1 finding from 1 review

Free spectacles vs no free spectacles (prescription only)

Uncorrected visual acuity deficit due to refractive error · school‐age children and adolescents

The review found no eligible studies for this question.

2 findings from 1 review

Ready‐made vs custom‐made spectacles

Uncorrected visual acuity deficit due to refractive error · school‐age children and adolescents
2 findings from 1 review