Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Omega‐3 (with risperidone and previous ASM) vs risperidone and previous ASM only

Proportion of individuals withdrawing from treatment · people with ADHD and epilepsy

Omega‐3 (with risperidone and previous ASM) showed no clear difference in proportion of individuals withdrawing from treatment compared with risperidone and previous ASM only (low certainty).

1 finding from 1 review

Summary of findings: endovenous ablation and compression vs compression alone

Ulcer healing time (measured as days from randomisation and followed‐up to 1 year) · people with venous leg ulcers

Summary of findings: endovenous ablation and compression leads to higher ulcer healing time (measured as days from randomisation and… compared with compression alone (high certainty).

1 finding from 1 review

Summary of findings: endovenous ablation and compression vs compression alone

The proportion of pressure ulcers healed · people with venous leg ulcers

Summary of findings: endovenous ablation and compression showed no clear difference in proportion of ulcers healed at 90 days (90 days compared with compression alone (moderate certainty).

2 findings from 1 review

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
    6 studies
    GRADE not reported

Subperiosteal prepared (SPP) wound closure after tooth extraction vs Epiperiosteal prepared (EPP) wound closure after tooth extraction

MRONJ after tooth extraction (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)

Subperiosteal prepared (SPP) wound closure after tooth extraction showed no clear difference in MRONJ after tooth extraction (incidence proportion) compared with epiperiosteal prepared (EPP) wound closure after tooth extraction (low certainty).

1 finding from 1 review

Summary of findings table ‐ Oral classical immunosuppressants (betamethasone) vs oral classical immunosuppressants (azathioprine, methotrexate, prednisolone)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral classical immunosuppressants… showed no clear difference in short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with oral classical immunosuppressants (azathioprine, methotrexate,… (low certainty).

1 finding from 1 review