Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,062 questions · 1,113 findings · 171 reviews · Headline outcomes only

No studies found 161 · 14.5%GRADE not reported 41 · 3.7%Very low 269 · 24.2%Low 321 · 28.8%Moderate 252 · 22.6%High 69 · 6.2%

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 34 weeks' gestation · Women with a multiple pregnancy

Intramuscular (IM) progesterone may leads to higher preterm birth less than 34 weeks compared with no treatment or placebo (low certainty).

1 finding from 1 review

Intramuscular (IM) progesterone vs no treatment or placebo

Preterm birth less than 28 weeks · Women with a multiple pregnancy

Intramuscular (IM) progesterone showed no clear difference in preterm birth less than 28 weeks compared with no treatment or placebo (moderate certainty).

1 finding from 1 review

Exercise vs control immediately post intervention

Adverse events The timing of measurement was post‐intervention for all studies · people with multiple sclerosis

Exercise showed no clear difference in adverse events The timing of measurement was post‐intervention for… compared with control (post‐intervention) (low certainty).

1 finding from 1 review

Palliative care vs usual care

Adverse effects: at least one serious adverse event · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…

Palliative care showed no clear difference in serious adverse events Assessed by: number of participants… compared with usual care (low certainty).

1 finding from 1 review

Palliative care vs usual care

Hospital admissions · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…

Palliative care showed no clear difference in hospital admission Assessed by: number of participants admitted in… compared with usual care (low certainty).

1 finding from 1 review