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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

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No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Total hip arthroplasty vs hemiarthroplasty

Activities of daily living · adults with displaced and undisplaced hip fractures

It is very uncertain whether total hip arthroplasty changes activities of daily living, early (within 4 months): using Katz… compared with hemiarthroplasty (very low certainty).

1 finding from 1 review

Total hip arthroplasty vs hemiarthroplasty

Functional status, early (within 4 months): using HHS (range from 0 to 100) and Johansen hip score (range from 0 to 100); higher scores indicate better function · adults with displaced and undisplaced hip fractures
1 finding from 1 review

Total hip arthroplasty vs hemiarthroplasty

Mortality, early (within 4 months) · adults with displaced and undisplaced hip fractures

It is very uncertain whether total hip arthroplasty changes mortality, early (within 4 months) compared with hemiarthroplasty (very low certainty).

1 finding from 1 review

Cemented vs uncemented hemiarthroplasty

Functional status, early (within 4 months): using HHS (range from 0 to 100) and Johansen hip score (range from 0 to 100); higher scores indicate better function · adults with displaced and undisplaced hip fractures
1 finding from 1 review

Cemented vs uncemented hemiarthroplasty

Mobility, early (within 4 months): able to walk outdoors using no more than 1 walking aid. · adults with displaced and undisplaced hip fractures

Cemented showed no clear difference in mobility, early (within 4 months): able to walk outdoors using no… compared with uncemented hemiarthroplasty (moderate certainty).

1 finding from 1 review

Cemented vs uncemented hemiarthroplasty

Mortality, early (within 4 months) · adults with displaced and undisplaced hip fractures

Cemented showed no clear difference in mortality, early (within 4 months) compared with uncemented hemiarthroplasty (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects – leaving the study early due to adverse effects –… compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · patients with schizophrenia

Summary of findings table ‐ Continuation may leads to lower leaving the study early due to any reason – overall acceptability… compared with reduction of polypharmacy (low certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Withdrawals due to adverse events · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction probably leads to higher adverse effect ‐ leaving the study early due to adverse effects ‐… compared with dose continuation (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction probably leads to higher leaving the study early ‐ for any reason ‐ overall acceptability… compared with dose continuation (moderate certainty).

1 finding from 1 review