Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

828 questions · 1,477 findings · 103 reviews

No studies found 5 · 0.3%GRADE not reported 1,402 · 94.9%Very low 38 · 2.6%Low 20 · 1.4%Moderate 11 · 0.7%High 1 · 0.1%

Early childhood caries (ECC) vs Caries-free controls

Streptococcus mutans and Veillonella spp. levels · Young children with early childhood caries and caries-free controls

Veillonella spp. levels were reported as substantially greater in caries subjects, but the review gave no numerical effect estimate or CI.

1 finding from 1 review

Early childhood caries (ECC) vs NA (within-white-spot-lesion correlation, not a caries vs caries-free comparison)

Correlation of Veillonella spp. with acidogenic streptococci · Young children with early childhood caries and caries-free controls

Veillonella spp. levels were correlated with acidogenic streptococci in white spot lesions (r²=0.38); no CI was reported.

1 finding from 1 review

Higher per-capita expenditure on dental health care vs Lower per-capita expenditure on dental health care (USD bands: $0-50 / $51-100 / >$100)

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)

Countries with higher per-capita dental expenditure had lower mean DMFT (>$100: 0.96; $51-100: 2.14; $0-50: 3.06) (Figure 4); not GRADE-rated.

3 findings from 1 review

Severe early childhood caries vs Caries-free controls

Relative abundance of Veillonella spp. · Children under 6 years with severe early childhood caries and caries-free controls

Veillonella spp. mean relative abundance was lower in the S-ECC group; no comparative effect estimate or CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Relative abundance of S. mutans in saliva · Children under 6 years with severe early childhood caries and caries-free controls

S. mutans median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Streptococcus relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Streptococcus mean relative abundance was slightly higher in the S-ECC group; no comparative effect estimate or CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella spp. and Streptococcus mutans interaction · Children under 6 years with severe early childhood caries and caries-free controls

The study reported a possible role for Veillonella spp. in supporting cariogenic species, without a quantitative effect estimate.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella dispar relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Veillonella dispar median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review