What do systematic reviews say?

BENZODIAZEPINES AS SOLE TREATMENT vs placebo

It is very uncertain whether BENZODIAZEPINES AS SOLE TREATMENT changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO (very low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 0.89 [0.57, 1.38]
  8 studies · 440 participants
  Very low

Benzodiazepines vs antipsychotics

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to any reason (overall acceptability of… compared with ANTIPSYCHOTICS (very low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 0.73 [0.45, 1.18]
  13 studies · 738 participants
  Very low

Knee length vs compression stockings

It is very uncertain whether knee length changes deep vein thrombosis (Fixed‐effect analysis) Venous duplex scan,… compared with thigh length graduated compression stockings (very low certainty).

• Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in… 2012 · Cochrane Headline outcomes only
  OR 1.55 [0.78, 3.07]
  3 studies · 496 participants
  Very low
• Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in… 2012 · Cochrane Headline outcomes only
  OR 1.32 [0.43, 4.06]
  3 studies · 496 participants
  Very low
• Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 496 participants
  Very low

Intervention not reported

• Mobile phone messaging for preventive health care 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Very low

Summary of findings: Email as additional communication method vs standard mail

• Email for the provision of information on disease prevention and health promotion 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1859 participants
  Very low

Amitriptyline vs placebo

It is very uncertain whether amitriptyline changes acceptability of treatment Drop‐out for any reason compared with placebo (very low certainty).

• Amitriptyline versus placebo for major depressive disorder 2012 · Cochrane Headline outcomes only
  OR 0.71 [0.55, 0.93]
  24 studies · 2400 participants
  Very low

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

• Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
  The majority of patients preferred inhalation sedation over hypnosis. (Braithwaite 2005; 10 patients.)
  1 study · 10 participants
  GRADE not reported

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

The review found no eligible studies for this question.

• Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes

  Minimum 3 months (planned)
  no estimate extracted
  0 studies
  No studies found

Systemic oral acyclovir vs placebo or no treatment

• Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes
  Amir 1997b: no data available. Ducoulombier 1988: tolerance and acceptability of the drug was described as satisfactory, but it was unclear how this was assessed by the trialists.
  1 study
  GRADE not reported

Minimal incision palatopharyngoplasty (MIPP) vs MIPP with additional individualised velopharyngeal surgery (pharyngeal flap or sphincter pharyngoplasty)

The review found no eligible studies for this question.

• Interventions for the management of submucous cleft palate 2008 · Cochrane All outcomes
  The trial report provided no information on this adverse event; no information on adverse events or serious complications was reported.
  0 studies
  No studies found

Tongue scraper or tongue cleaner (One Drop Only tongue cleaner; Tongue-Putzer scraper; polystyrene scraper) vs Toothbrush (used to clean the tongue)

• Tongue scraping for treating halitosis 2006 · Cochrane All outcomes

  1 week (Pedrazzi 2004)
  Pedrazzi 2004: six of ten (60%) participants complained of nausea and one participant of tongue trauma, only with the toothbrush; all participants were receptive to the tongue scraper. Seemann 2001: no adverse effects…
  2 studies
  GRADE not reported

Fluoride toothpaste vs Fluoride mouthrinse

Fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.

• One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
  RR 0.89 [0.78, 1.00]
  5 studies
  GRADE not reported

Fluoride mouthrinse (0.05-0.32% sodium fluoride or amine fluoride) added to daily fluoride toothpaste vs Fluoride mouthrinse

Fluoride mouthrinse combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride mouthrinse alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 0.88 [0.67, 1.17]
  3 studies · 1697 participants
  GRADE not reported

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Fluoride gel combined with fluoride mouthrinse showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride gel alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 1.00 [0.72, 1.40]
  1 study · 344 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride varnish

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride varnish alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 0.75 [0.22, 2.59]
  1 study · 196 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 1.29 [0.61, 2.71]
  2 studies · 294 participants
  GRADE not reported

Fluoride varnish vs Fluoride toothpaste alone

Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride toothpaste; GRADE not reported.

• One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
  RR 1.28 [0.37, 4.41]
  1 study
  GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Fluoride mouthrinse, gel or varnish combined with fluoride… showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
  RR 1.06 [0.93, 1.22]
  5 studies · 1998 participants
  GRADE not reported

Fluoride toothpaste vs Any other topical fluoride (gel or mouthrinse)

Fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs) compared with any other topical fluoride (gel or mouthrinse); GRADE not reported.

• One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries… 2004 · Cochrane All outcomes
  RR 0.88 [0.78, 1.00]
  6 studies
  GRADE not reported