Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,268 questions · 1,343 findings · 197 reviews

No studies found 317 · 23.6%GRADE not reported 189 · 14.1%Very low 356 · 26.5%Low 271 · 20.2%Moderate 173 · 12.9%High 37 · 2.8%

Intervention not reported

Episodes of febrile neutropenia · patients with prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in episodes of febrile neutropenia (moderate certainty).

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Pain-free maximum jaw opening (mm), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in pain-free maximum jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Arthroscopy vs Arthrocentesis

Maximal mouth opening (interincisal distance) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy led to higher maximum interincisal opening (mm) after 12 months compared with arthrocentesis; GRADE not reported.

1 finding from 1 review

Radioisotopes vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · patients with metastatic bone pain

Radioisotopes showed no clear difference in thrombocytopenia III‐IV compared with placebo (low certainty).

1 finding from 1 review

Radioisotopes vs placebo

Leucocytopenia III‐IV · patients with metastatic bone pain

Radioisotopes may leads to higher leucocytopenia III‐IV compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Average reduction in mean speed 2.3 km/h (p = 0.05) at camera sites post 1st year. Average reduction in mean speeds 1.3 km/h (‐2.6 to 0.1)post 2nd year on experimental open roads
1 finding from 1 review

Intervention not reported

Over the first 2 years of the study mean speeds fell by 1.3 km/h (‐2.6 to 0.1) and 85th percentile speeds reduced by 4.3 km/h on open roads generally,compared with the rest of the country.
1 finding from 1 review

Intervention not reported

Having controlled for season and general trends, injury crash outcomes in experimental areas relative to control areas were a net reduction of 11% (p= 0.03) in all crashes and 19% (p=0.002) in injury crashes on open roads across the region associa...

The review found no eligible studies for this question.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Trismus / maximum mouth opening (mean) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage led to lower maximum incisal (mouth) opening (MIO) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Clicks in TMJ on oral opening and closing · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in clicks in TMJ on oral opening and closing compared with transcutaneous electric nerve stimulation (TENS); GRADE not reported.

2 findings from 1 review

Stabilisation splint (SS) vs Non-occluding splint

Movement (increase in maximal mouth opening) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity

Stabilisation splint (SS) showed no clear difference in movement (increase in maximal mouth opening) compared with non-occluding splint; GRADE not reported.

1 finding from 1 review

Stabilisation splint (SS) vs relaxation

Maximal mouth opening (interincisal distance) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity
1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes time to wound healing (days) compared with conventional open wound healing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes proportion of wounds healed at 30 days compared with conventional open wound healing (very low certainty).

3 findings from 1 review

Negative pressure wound therapy vs conventional open wound healing

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

1 finding from 1 review