Findings

What do systematic reviews say?

2,209 questions · 2,322 findings · 227 reviews · Headline outcomes only

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No studies found 644 · 27.7%GRADE not reported 135 · 5.8%Very low 591 · 25.5%Low 582 · 25.1%Moderate 309 · 13.3%High 61 · 2.6%

Lamotrigine vs placebo

Recurrence of any episodes at one year (active suicidal behavior) · bipolar disorder

1 finding from 1 review

Lamotrigine in the maintenance treatment of bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
GRADE not reported

Spectacle correction vs no spectacles

Proportion of children without refractive error in the emmetropization range at 3 years · infants or children with hyperopia

It is very uncertain whether spectacle correction changes proportion of children without refractive error in the… compared with no spectacles (very low certainty).

1 finding from 1 review

Spectacle correction versus no spectacles for prevention of strabismus in hyperopic children 2020 · Cochrane Headline outcomes only
RR 0.75 [0.18, 3.19]
1 study · 106 participants
Very low

Intervention not reported

Behavioural predictors of car use Intention to use active transport after obtaining a driving licence. Measured pre‐ and postintervention, and at 8 weeks' · teenagers, aged 17–19 years

1 finding from 1 review

Mobility management to prevent, reduce, or delay driving a car in teenagers 2020 · Cochrane Headline outcomes only
no estimate extracted
860 participants
Very low

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome vs LASIK with a femtosecond laser

Mean refractive error expressed as mean spherical equivalent post‐treatment. ‐ 12 months · adults (18 years) with more than 0.5 diopters of myopia or myopic astigmatism

1 finding from 1 review

Laser‐assisted in‐situ keratomileusis (LASIK) with a mechanical microkeratome compared to LASIK with a femtosecond… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 168 participants
Low

Intervention not reported

No active treatment (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes no active treatment (No direct RCT) (very low certainty).

1 finding from 1 review

Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 1.66 [0.46, 6.99]
Studies not reported
Very low

Intervention not reported

No active intervention · people with liver cirrhosis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a network… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

No active intervention (only maintenance immunosuppression) (1 RCT; 45 participants) · adults undergoing liver transplantation

It is very uncertain whether the intervention changes no active intervention (only maintenance immunosuppression) (1 RCT;… (very low certainty).

1 finding from 1 review

Induction immunosuppression in adults undergoing liver transplantation: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.76 [0.12, 4.59]
Studies not reported
Very low

Intervention not reported

No active intervention (1 RCT; 45 participants) · adults undergoing liver transplantation

It is very uncertain whether the intervention changes no active intervention (1 RCT; 45 participants) (very low certainty).

1 finding from 1 review

Induction immunosuppression in adults undergoing liver transplantation: a network meta‐analysis 2020 · Cochrane Headline outcomes only
HR 0.75 [0.18, 3.13]
Studies not reported
Very low

Botulinum toxin plus conservative treatment vs conservative treatment

Active range of motion of the ankle joint · children with ITW gait

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for idiopathic toe walking 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

Postoperative residual refractive astigmatism of less than 0.50 D · people with astigmatism who are having cataract surgery (phacoemulsification)

Toric intraocular lens (IOL) probably leads to higher postoperative residual refractive astigmatism of less than 0.50 D compared with limbal relaxing incisions (LRIs) (moderate certainty).

1 finding from 1 review

Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification 2019 · Cochrane Headline outcomes only
RR 1.4 [1.1, 1.78]
5 studies · 262 participants
Moderate

Toric intraocular lens (IOL) vs limbal relaxing incisions (LRIs)

Postoperative residual refractive astigmatism in dioptres · people with astigmatism who are having cataract surgery (phacoemulsification)

1 finding from 1 review

Toric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 620 participants
Low

MVA85A vs placebo

Active tuberculosis: confirmed by culture or Xpert® MTB/RIF longest reported · HIV‐positive and ‐negative adults and children

MVA85A showed no clear difference in active tuberculosis: confirmed by culture or Xpert® MTB/RIF longest… compared with placebo (moderate certainty).

1 finding from 1 review

MVA85A vaccine to enhance BCG for preventing tuberculosis 2019 · Cochrane Headline outcomes only
RR 0.97 [0.58, 1.62]
2 studies · 3439 participants
Moderate

MVA85A vs placebo

Active tuberculosis: started on tuberculosis treatment · HIV‐positive and ‐negative adults and children

MVA85A showed no clear difference in active tuberculosis: started on tuberculosis treatment compared with placebo (moderate certainty).

1 finding from 1 review

MVA85A vaccine to enhance BCG for preventing tuberculosis 2019 · Cochrane Headline outcomes only
RR 1.1 [0.92, 1.33]
3 studies · 3687 participants
Moderate

Macrolide+tetracycline vs macrolides

Change in baseline trough FEV1 · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 182 participants
Very low

Aquablation vs transurethral resection of the prostate

Erectile function · men with benign prostatic hyperplasia

1 finding from 1 review

Aquablation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 64 participants
Very low

Aquablation vs transurethral resection of the prostate

Ejaculatory function · men with benign prostatic hyperplasia

1 finding from 1 review

Aquablation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 121 participants
Very low

Free spectacles vs no free spectacles (prescription only)

Uncorrected visual acuity deficit due to refractive error · school‐age children and adolescents

The review found no eligible studies for this question.

2 findings from 1 review

Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Educational intervention vs no educational intervention

Visual acuity deficit due causes other than refractive error · school‐age children and adolescents

The review found no eligible studies for this question.

1 finding from 1 review

Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ready‐made vs custom‐made spectacles

Uncorrected visual acuity deficit due to refractive error · school‐age children and adolescents

2 findings from 1 review

Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 414 participants
Moderate
Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ready‐made vs custom‐made spectacles

Visual acuity deficit due causes other than refractive error · school‐age children and adolescents

The review found no eligible studies for this question.

1 finding from 1 review

Vision screening for correctable visual acuity deficits in school‐age children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found