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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Population

Intervention or exposure

Comparison

Outcome

Any field or review title

Field or topic

Source

Review versions

1,645 questions in 107 reviews · Wounds

current versions

No studies 651 · 39.6%Ungraded 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
NPWT 125 mmHg vs NPWT 75 mmHg Adverse events · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
NPWT 125 mmHg vs NPWT 75 mmHg Time to closure or coverage surgery · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
NPWT 125 mmHg vs standard care Wound infection · open fracture wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	RR 0.48 [0.2, 1.13]	4 studies · 596 participants	Very low
NPWT 125 mmHg vs NPWT 75 mmHg Pain · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
NPWT 125 mmHg vs standard care Adverse events · open fracture wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	1 study · 460 participants	Ungraded
NPWT 125 mmHg vs standard care Time to closure or coverage surgery (days) · open fracture wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	2 studies · 151 participants	Very low
NPWT 125 mmHg vs standard care Pain · open fracture wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
NPWT 125 mmHg vs standard care Complete wound healing · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
NPWT 125 mmHg vs standard care Wound infection · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	RR 0.61 [0.31, 1.18]	2 studies · 509 participants	Low
NPWT 125 mmHg vs standard care Adverse events · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
NPWT 125 mmHg vs standard care Time to closure or coverage surgery · other open traumatic wounds Negative pressure wound therapy for open traumatic wounds (2018) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Contrasts · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Foam versus nonadherent dressing · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 1.15 [0.91, 1.44]	NR	Low
Intervention NR Hydrocolloid versus nonadherent dressing · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 1.04 [0.85, 1.29]	NR	Very low
Intervention NR Sucralfate versus nonadherent · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 6.8 [2.24, 20.7]	NR	Low
Intervention NR Sucralfate versus foam · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 5.94 [1.96, 18]	NR	Low
Intervention NR Sucralfate versus hydrocolloid · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 6.51 [2.17, 19.6]	NR	Low
Intervention NR Silver versus nonadherent · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 2.43 [1.58, 3.74]	NR	Moderate
Intervention NR Silver versus foam · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 2.12 [1.46, 3.07]	NR	Low
Intervention NR Silver versus hydrocolloid · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 2.32 [1.58, 3.41]	NR	Low
Intervention NR Sucralfate versus silver · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 2.8 [0.88, 8.97]	NR	Very low
Intervention NR Foam versus hydrocolloid · people with venous leg ulcers Dressings and topical agents for treating venous leg ulcers (2018) · Cochrane	RR 1.1 [0.93, 1.28]	NR	Very low
High frequency ultrasound vs no ultrasound Proportion of ulcers completely healed at 3 weeks · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 2.05 [0.24, 17.23]	1 study · 65 participants	Very low
High frequency ultrasound vs no ultrasound Cost · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	1 study · 337 participants	Moderate
Low frequency ultrasound vs no ultrasound Proportion of ulcers completely healed at 8 to 12 weeks · venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 3.91 [0.47, 32.85]	2 studies · 61 participants	Very low
Low frequency ultrasound vs no ultrasound Adverse events · venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Low frequency ultrasound vs no ultrasound HRQoL · venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Low frequency ultrasound vs no ultrasound Cost · venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
High frequency ultrasound vs no ultrasound Proportion of ulcers completely healed at 7 or 8 weeks: losses to · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 1.21 [0.86, 1.71]	6 studies · 678 participants	Low
High frequency ultrasound vs no ultrasound Proportion of ulcers completely healed at 12 weeks: losses to · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 1.26 [0.92, 1.73]	3 studies · 489 participants	Moderate
High frequency ultrasound vs no ultrasound Healing at 12 months (nurse‐reported data) · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 0.93 [0.73, 1.18]	1 study · 337 participants	Low
High frequency ultrasound vs no ultrasound Change in ulcer size at 4 or 7 weeks · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	2 studies · 165 participants	Very low
High frequency ultrasound vs no ultrasound Non‐serious adverse events · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 1.29 [1.02, 1.64]	1 study · 337 participants	Moderate
High frequency ultrasound vs no ultrasound Serious adverse events · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	RR 1.21 [0.78, 1.89]	1 study · 337 participants	Moderate
High frequency ultrasound vs no ultrasound HRQoL: 12‐week SF‐12 mean Physical/Mental Component Scores scale from 0 to 100 · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	1 study · 285 participants	Moderate
High frequency ultrasound vs no ultrasound HRQoL: 12‐month SF‐12 Physical Component Score Scale from: 0 to 100 · people with venous leg ulcers Therapeutic ultrasound for venous leg ulcers (2017) · Cochrane	no estimate extracted	1 study · 229 participants	Moderate
Scalpel vs electrosurgery Wound infection · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	RR 1.07 [0.74, 1.54]	11 studies · 2178 participants	Low
Scalpel vs electrosurgery Time to wound healing (days) · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	no estimate extracted	NR	No studies
Scalpel vs electrosurgery Wound dehiscence · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	RR 1.21	6 studies · 1064 participants	Very low
Scalpel vs electrosurgery Postoperative pain · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	no estimate extracted	9 studies · 949 participants	Ungraded
Scalpel vs electrosurgery Wound incision time (seconds) · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	no estimate extracted	4 studies · 325 participants	Moderate
Scalpel vs electrosurgery Wound‐related blood loss (mL) · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	no estimate extracted	3 studies · 241 participants	Moderate
Scalpel vs electrosurgery Adhesion or scar formation · people undergoing surgery involving major abdominal incisions Scalpel versus electrosurgery for major abdominal incisions (2017) · Cochrane	no estimate extracted	1 study · 84 participants	Ungraded
Topical phenytoin vs hydrocolloid dressing Time to complete healing · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Topical phenytoin group vs a simple dressing Proportion of ulcers healed within trial period (eight weeks) · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	RR 1.33 [0.63, 2.78]	1 study · 55 participants	Very low
Topical phenytoin group vs a simple dressing Adverse events · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	2 studies · 81 participants	Ungraded
Topical phenytoin group vs a simple dressing Pain · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	NR	No studies
Topical phenytoin vs hydrocolloid dressing Proportion of ulcers healed within trial period (eight weeks) · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	RR 0.55 [0.33, 0.92]	1 study · 56 participants	Low
Topical phenytoin vs hydrocolloid dressing Adverse events · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	2 studies · 84 participants	Ungraded
Topical phenytoin vs hydrocolloid dressing Pain · people with a pressure ulcer Topical phenytoin for treating pressure ulcers (2017) · Cochrane	no estimate extracted	1 study · 28 participants	Ungraded