Cardiac SAEs · people who smoke
Varenicline showed no clear difference in cardiac SAEs compared with combination nicotine replacement therapy (low certainty).
1 finding from 1 review
Overall survival (OS) · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy showed no clear difference in overall survival (OS) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
Progression‐free survival · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy probably leads to lower progression‐free survival (PFS) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
QoL · platinum‐sensitive recurrent EOC
1 finding from 1 review
Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy showed no clear difference in overall severe adverse events (grade ≥ 3) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
Anaemia (grade ≥ 3) · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy probably leads to higher anaemia (grade ≥ 3) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
Hand‐foot syndrome (grade ≥ 3) · platinum‐sensitive recurrent EOC
It is very uncertain whether summary of findings 1: PLD with chemotherapy changes hand‐foot syndrome (grade ≥ 3) compared with alternative combination chemotherapy (very low certainty).
1 finding from 1 review
Neurological (grade ≥ 3) · platinum‐sensitive recurrent EOC
It is very uncertain whether summary of findings 1: PLD with chemotherapy changes neurological (grade ≥ 3) compared with alternative combination chemotherapy (very low certainty).
1 finding from 1 review
Breakthrough pain · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
Automated mandatory bolus probably leads to lower breakthrough pain compared with basal infusion (moderate certainty).
1 finding from 1 review
Caesarean delivery during labour epidural analgesia · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
Automated mandatory bolus showed no clear difference in caesarean delivery during labour epidural analgesia compared with basal infusion (moderate certainty).
1 finding from 1 review
Instrumental delivery during labour epidural analgesia · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
Automated mandatory bolus showed no clear difference in instrumental delivery during labour epidural analgesia compared with basal infusion (moderate certainty).
1 finding from 1 review
Duration of labour analgesia in minutes · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
1 finding from 1 review
Local anaesthetic consumption per hour (mg/hr)c during labour epidural analgesia · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
1 finding from 1 review
Maternal satisfaction following fetal delivery · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
1 finding from 1 review
APGAR score (APGAR score ) · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
1 finding from 1 review
Smoking cessation ‐ 16 weeks versus 8 weeks · people who smoke
It is very uncertain whether longer changes smoking cessation ‐ 16 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).
1 finding from 1 review
Smoking cessation · people who smoke
Longer showed no clear difference in smoking cessation ‐ 6 weeks versus 2 weeks compared with shorter duration of combination nicotine replacement therapy (low certainty).
1 finding from 1 review
SAEs · people who smoke
It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).
3 findings from 1 review
RR 1.63 [0.6, 4.42]
1 study · 544 participants
Very low
no estimate extracted
1 study · 637 participants
Very low
no estimate extracted
1 study · 987 participants
Very low
Treatment withdrawal · people who smoke
1 finding from 1 review
Intervention not reported
Index test result · of people with HIV‐negative or unknown HIV status who are considered eligible for systematic screening for tuberculosis disease. Role of…
1 finding from 1 review
no estimate extracted
0 participants
GRADE not reported