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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

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No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Droperidol vs midazolam

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol showed no clear difference in global state: use of additional medication ‐ by 60 minutes after… compared with midazolam (moderate certainty).

1 finding from 1 review

Droperidol vs placebo

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with placebo (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with olanzapine (high certainty).

1 finding from 1 review

Droperidol vs haloperidol

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with haloperidol (high certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Movement disorder requiring the use of anti‐EPS medication ‐ medium term · patients with schizophrenia

RISPERIDONE DEPOT probably leads to higher adverse events: Movement disorder requiring the use of anti‐EPS… compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (moderate certainty).

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Osteoporosis medication 2 · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher osteoporosis medication 2 compared with standard care (high certainty).

1 finding from 1 review

Primary care physician alerting system vs usual care

Osteoporosis medication2 · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system probably leads to higher osteoporosis medication2 compared with usual care (moderate certainty).

1 finding from 1 review

Primary care physician alerting system vs primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician)

Medication2 · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system showed no clear difference in medication2 compared with primary care physician alerting system and a patient‐directed… (moderate certainty).

1 finding from 1 review