Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

611 questions · 621 findings · 112 reviews

No studies found 53 · 8.5%GRADE not reported 70 · 11.3%Very low 91 · 14.7%Low 216 · 34.8%Moderate 152 · 24.5%High 39 · 6.3%

Summary of findings table for oral immunoglobulin vs control

NEC‐related deaths during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related deaths during study period compared with control (very low certainty).

1 finding from 1 review

Ambroxol vs corticosteroid (betamethasone)

Perinatal mortality frequency of deaths of newborns · women at risk of preterm birth

Ambroxol showed no clear difference in perinatal mortality frequency of deaths of newborns compared with corticosteroid (betamethasone) (moderate certainty).

1 finding from 1 review

Ambroxol vs corticosteroid (betamethasone)

Adverse effects in pregnant women frequency in pregnant women · women at risk of preterm birth

It is very uncertain whether ambroxol changes adverse effects in pregnant women frequency in pregnant women compared with corticosteroid (betamethasone) (very low certainty).

1 finding from 1 review

Ambroxol vs placebo or no treatment

Other events in newborns ‐ Administration of pulmonary surfactant frequency in newborns · women at risk of preterm birth

Ambroxol showed no clear difference in other events in newborns ‐ Administration of pulmonary surfactant… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Ambroxol vs placebo or no treatment

Other events in newborns ‐ Need for mechanical ventilation frequency inf newborns · women at risk of preterm birth

Ambroxol showed no clear difference in other events in newborns ‐ Need for mechanical ventilation frequency… compared with placebo or no treatment (low certainty).

1 finding from 1 review