Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,289 questions · 2,331 findings · 195 reviews · Pregnancy and Childbirth

No studies found 480 · 20.6%GRADE not reported 288 · 12.4%Very low 467 · 20%Low 630 · 27%Moderate 338 · 14.5%High 128 · 5.5%

Pyridoxine vs placebo

Severity, reduction or cessation in nausea/vomiting 2. Quality of life outcomes 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Metoclopramide vs ondansetron

Severity, reduction or cessation in nausea/vomiting 2.Days of hospital admission 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture vs placebo

Preterm birth · Pregnant women with hyperemesis gravidarum

Acupuncture showed no clear difference in preterm birth less than 37 weeks compared with placebo (low certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Days of hospital admission 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Ondansetron vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Quality of life outcomes 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids vs placebo

Pregnancy complications · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes pregnancy complications compared with placebo (very low certainty).

1 finding from 1 review

Group antenatal care vs individual antenatal care (adjusted data)

Gestational age (preterm birth < 37 weeks) · pregnant women accessing prenatal care

Group antenatal care showed no clear difference in preterm birth (gestational age at time of birth less than 37 weeks'… compared with individual antenatal care (adjusted data) (moderate certainty).

1 finding from 1 review

Anti‐D administration in pregnancy vs no treatment

Incidence of Rhesus D alloimmunisation postpartum (at birth of Rh‐positive infant and at · Rh‐negative women without anti‐D antibodies

Anti‐D administration in pregnancy showed no clear difference in incidence of Rhesus D alloimmunisation postpartum (at birth of… compared with no treatment (low certainty).

1 finding from 1 review

Anti‐D administration in pregnancy vs no treatment

Incidence of positive Kleihauer test (at 32 to 35 weeks' gestation) · Rh‐negative women without anti‐D antibodies

Anti‐D administration in pregnancy may leads to lower incidence of positive Kleihauer test (at 32 to 35 weeks' gestation) compared with no treatment (low certainty).

1 finding from 1 review

Anti‐D administration in pregnancy vs no treatment

Incidence of positive Kleihauer test (at birth of a Rh‐positive infant) · Rh‐negative women without anti‐D antibodies

Anti‐D administration in pregnancy may leads to lower incidence of positive Kleihauer test (at birth of a Rh‐positive… compared with no treatment (low certainty).

1 finding from 1 review