Findings

What do systematic reviews say?

625 questions · 647 findings · 67 reviews · Pregnancy and Childbirth

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No studies found 83 · 12.8%GRADE not reported 70 · 10.8%Very low 141 · 21.8%Low 227 · 35.1%Moderate 97 · 15%High 29 · 4.5%

Erythromycin vs placebo

Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection

Erythromycin probably leads to higher microbiological cure compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for treating genital Chlamydia trachomatis infection in pregnancy 2017 · Cochrane Headline outcomes only
RR 2.64 [1.6, 4.38]
2 studies · 495 participants
Moderate

Clindamycin vs placebo

Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection

Clindamycin may leads to higher microbiological cure compared with placebo (low certainty).

1 finding from 1 review

Interventions for treating genital Chlamydia trachomatis infection in pregnancy 2017 · Cochrane Headline outcomes only
RR 4.08 [2.35, 7.08]
1 study · 85 participants
Low

Amoxicillin vs placebo

Microbiological cure · Pregnant women with a confirmed Chlamydia trachomatis infection

It is very uncertain whether amoxicillin changes microbiological cure compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating genital Chlamydia trachomatis infection in pregnancy 2017 · Cochrane Headline outcomes only
RR 2 [0.59, 6.79]
1 study · 15 participants
Very low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ pregnancy · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ pregnancy compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 1.9 [0.57, 6.38]
1 study · 365 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Low birthweight · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in low birthweight compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.56 [0.26, 1.23]
2 studies · 377 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal hypothyroidism or elevated TSH · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal hypothyroidism or elevated TSH compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.58 [0.11, 3.12]
1 study · 219 participants
Very low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal adverse effect: elevated TPO‐ab · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal adverse effect: elevated TPO‐ab compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.61 [0.07, 5.7]
1 study · 108 participants
Very low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Child adverse effect: hyperthyroidism · women during the preconception, pregnancy and postpartum period

The review found no eligible studies for this question.

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.44 [0.06, 3.42]
3 studies · 540 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Preterm birth · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in preterm birth compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.71 [0.3, 1.66]
2 studies · 376 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: elevated thyroid peroxidase antibodies ‐ pregnancy · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: elevated thyroid peroxidase antibodies ‐… compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.95 [0.44, 2.07]
1 study · 359 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: elevated TPO‐ab ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: elevated TPO‐ab ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 1.01 [0.78, 1.3]
3 studies · 397 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: hyperthyroidism ‐ pregnancy · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: hyperthyroidism ‐ pregnancy compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 1.9 [0.57, 6.38]
1 study · 365 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: hyperthyroidism ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal adverse effect: hyperthyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.32 [0.11, 1.91]
3 studies · 543 participants
Low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal adverse effect: digestive intolerance ‐ pregnancy · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes maternal adverse effect: digestive intolerance ‐ pregnancy compared with same supplement without iodine or no treatment/placebo (maternal… (very low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 15.33 [2.07, 113.7]
1 study · 76 participants
Very low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Perinatal mortality · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in perinatal mortality compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Iodine supplementation for women during the preconception, pregnancy and postpartum period 2017 · Cochrane Headline outcomes only
RR 0.66 [0.42, 1.03]
1 study · 399 participants
Low

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Hypertensive disorders of pregnancy · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes hypertensive disorders of pregnancy ‐ (any type) compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 1.24 [0.81, 1.9]
1 study · 375 participants
Very low

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Death or serious morbidity composite · Infants of women diagnosed with gestational diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Neonatal hypoglycaemia · Infants of women diagnosed with gestational diabetes

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes neonatal hypoglycaemia compared with placebo ‐ neonatal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 1.97 [0.36, 10.62]
1 study · 375 participants
Very low

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Adiposity (neonate, child, adult) ‐ not measured · Infants of women diagnosed with gestational diabetes

The review found no eligible studies for this question.

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found