Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,695 questions · 4,979 findings · 433 reviews

No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

NSAIDs vs placebo

Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes substantial pain relief: at least 50% reduction in pain, or PGIC… compared with placebo (very low certainty).

1 finding from 1 review

NSAIDs vs placebo

Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with fibromyalgia

It is very uncertain whether NSAID changes moderate pain relief: at least 30% reduction in pain, or PGIC much… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Participants with at least 30% or at least 50% reduction in pain · people with cancer pain
1 finding from 1 review

Intervention not reported

PGIC much or very much improved · people with cancer pain
1 finding from 1 review

Intervention not reported

Mean pain intensity at end of study · people with cancer pain
1 finding from 1 review

Intervention not reported

Pain no worse than mild at one or two weeks (or equivalent) · people with cancer pain
1 finding from 1 review