Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

side‐effects ‐ side‐effects causing abandon · prevention of reintubation

The review found no eligible studies for this question.

2 findings from 1 review

Antipsychotics vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ remission) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ remission)Depressive… compared with placebo (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ response) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ response)Depressive… compared with placebo (low certainty).

1 finding from 1 review