Cochrane · systematic review · CD013608
D‐mannose for preventing and treating urinary tract infections
Cooper, TE, Teng, C, Howell, M, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
4
No studies
10
Included studies
NR
No studies 10 · 71.4%Ungraded 0 · 0%Very low 4 · 28.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
D‐mannose (2 g) versus no treatment for preventing or treating urinary tract infections
Population: women with acute cystitis or history of recurrent acute cystitis (preventing and treating)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptomatic and bacteriuria confirmed UTI (positive culture) D‐mannose (2 g) vs no treatment | RR 0.24 [0.15, 0.39] | 1 study · 205 participants | Very low Downgraded: risk of bias, imprecision |
Symptomatic‐only UTI D‐mannose (2 g) vs no treatment | no estimate extracted | NR | No studies |
Asymptomatic bacteriuria D‐mannose (2 g) vs no treatment | no estimate extracted | NR | No studies |
Changes to previous treatment regimen D‐mannose (2 g) vs no treatment | no estimate extracted | NR | No studies |
Pain D‐mannose (2 g) vs no treatment | no estimate extracted | NR | No studies |
Cure/complete remission D‐mannose (2 g) vs no treatment | no estimate extracted | NR | No studies |
Adverse effects D‐mannose (2 g) vs no treatment | RR 16.84 [0.98, 287.92] | 1 study · 205 participants | Very low Downgraded: risk of bias, imprecision |
D‐mannose (2 g) versus nitrofurantoin (50 mg) for preventing or treating urinary tract infections
Population: women with acute cystitis or history of recurrent acute cystitis (preventing and treating)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Symptomatic and bacteriuria‐confirmed UTI (positive culture) D‐mannose (2 g) vs nitrofurantoin (50 mg) | RR 0.71 [0.39, 1.31] | 1 study · 206 participants | Very low Downgraded: risk of bias, imprecision |
Symptomatic only UTI D‐mannose (2 g) vs nitrofurantoin (50 mg) | no estimate extracted | NR | No studies |
Asymptomatic bacteriuria D‐mannose (2 g) vs nitrofurantoin (50 mg) | no estimate extracted | NR | No studies |
Changes to previous treatment regimen D‐mannose (2 g) vs nitrofurantoin (50 mg) | no estimate extracted | NR | No studies |
Pain D‐mannose (2 g) vs nitrofurantoin (50 mg) | no estimate extracted | NR | No studies |
Cure/complete remission D‐mannose (2 g) vs nitrofurantoin (50 mg) | no estimate extracted | NR | No studies |
Adverse effects D‐mannose (2 g) vs nitrofurantoin (50 mg) | RR 0.28 [0.13, 0.57] | 1 study · 206 participants | Very low Downgraded: risk of bias, imprecision |