Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,429 questions · 3,558 findings · 436 reviews

No studies found 660 · 18.5%GRADE not reported 375 · 10.5%Very low 727 · 20.4%Low 887 · 24.9%Moderate 709 · 19.9%High 200 · 5.6%

Low‐intensity pulsed ultrasound vs control

Delayed or non‐union (medium term) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

Low‐intensity pulsed ultrasound showed no clear difference in delayed or non‐union (medium term) compared with control (moderate certainty).

1 finding from 1 review

Low‐intensity pulsed ultrasound vs control

Adverse events ‐ total of adverse events (Skin irritation) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

It is very uncertain whether low‐intensity pulsed ultrasound changes adverse events Reported as skin irritation compared with control (very low certainty).

1 finding from 1 review

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Side effects · People with erosive oral lichen planus
1 finding from 1 review
  • Table 3 (Side-effects). Malhotra 2008: betamethasone oral mini-pulse - transient oedema over the face (7), oedema over hands and feet (4), epigastric discomfort (7), weakness/fatigue (5), loose stools (1), headache…
    1 study · 22 participants
    GRADE not reported

Betamethasone oral mini-pulse therapy vs Topical triamcinolone acetonide paste

Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus

Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.

1 finding from 1 review

Monthly pulsed high‐dose dexamethasone vs prednisolone

≥ 1 point improvement on INCAT disability score at 12 months · patients with chronic inflammatory demyelinating polyradiculoneuropathy

Monthly pulsed high‐dose dexamethasone may leads to higher ≥ 1 point improvement on INCAT disability score at 12 months compared with oral prednisolone (low certainty).

1 finding from 1 review