Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs Fluoride mouthrinse

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride varnish vs Non-fluoride (placebo) varnish

Number of participants with more severe DLs (score 3 or 4 versus 1 or 2) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Professionally-applied fluoride varnish (7700 ppm F ammonium… may leads to lower number of participants with more severe DLs (score 3 or 4 versus 1… compared with non-fluoride (placebo) varnish (low certainty).

1 finding from 1 review

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Composite resin for bonding brackets

Number of participants with more severe DLs of aesthetic concern · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Resin-modified glass ionomer cement for bonding orthodontic brackets showed no clear difference in number of participants with more severe DLs of aesthetic concern compared with light-cured composite resin for bonding brackets (low certainty).

1 finding from 1 review

Patient-used 250 ppm F mouthrinse (100 ppm amine F/150 ppm NaF), daily vs 0 ppm F placebo mouthrinse, daily

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range · adults and children with cystic fibrosis

The intervention showed no clear difference in ototoxicity An increase in auditory threshold of 20 dB or more over… (low certainty).

1 finding from 1 review

Auto‐CPAP vs fixed CPAP

Number of participants using machine for 4 or more hours per night · adults with a diagnosis of OSA

Auto‐CPAP showed no clear difference in number of participants using machine for 4 or more hours per night compared with fixed CPAP (low certainty).

1 finding from 1 review

Exercise vs NSAIDs

Use of rescue medication · young women with suspected primary dysmenorrhoea

It is very uncertain whether exercise changes use of rescue analgesic medication assessed by: number of women who… compared with non‐steroidal anti‐inflammatory drugs (NSAIDs) (very low certainty).

1 finding from 1 review