Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,156 questions · 1,179 findings · 198 reviews · Headline outcomes only

No studies found 250 · 21.2%GRADE not reported 43 · 3.6%Very low 236 · 20%Low 395 · 33.5%Moderate 208 · 17.6%High 47 · 4%

Benzodiazepines vs ANTIHISTAMINES + ANTIPSYCHOTICS

Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation

Benzodiazepines showed no clear difference in global state: need for additional medication ‐ medium termNumber of… compared with antihistamines plus antipsychotics (low certainty).

1 finding from 1 review

BENZODIAZEPINES + ANTIPSYCHOTICS vs same enzodiazepines

Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation

Benzodiazepines + antipsychotics showed no clear difference in global state: need for additional medication ‐ + haloperidol ‐… compared with same enzodiazepines (low certainty).

1 finding from 1 review

Benzodiazepines vs placebo

Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation

It is very uncertain whether benzodiazepines changes global state: need for additional medication ‐ medium termNumber of… compared with placebo (very low certainty).

1 finding from 1 review

COURT ORDERED OUTPATIENT COMMITMENT vs ENTIRELY VOLUNTARY CARE

Compliance with medication · people with severe mental disorders

COURT ORDERED OUTPATIENT COMMITMENT showed no clear difference in health service outcomes: 4. Compliance with medication by 11 to 12… compared with ENTIRELY VOLUNTARY CARE (low certainty).

1 finding from 1 review

Ahmed implant vs Baerveldt implant

Mean number of antiglaucoma medications at 1‐year · People with glaucoma

Ahmed implant probably leads to higher mean number of antiglaucoma medications at 1‐year compared with baerveldt implant (moderate certainty).

1 finding from 1 review

Ahmed implant vs Molteno implant

Mean number of antiglaucoma medications at 1‐year · People with glaucoma

Ahmed implant showed no clear difference in mean number of antiglaucoma medications at 1‐year compared with molteno implant (low certainty).

1 finding from 1 review

Molteno implant vs Schocket shunt

Mean number of antiglaucoma medications at 1‐year · People with glaucoma

The review found no eligible studies for this question.

1 finding from 1 review

Aqueous shunts vs trabeculectomy

Mean number of antiglaucoma medications at 1‐year · People with glaucoma

Aqueous shunts may leads to higher mean number of antiglaucoma medications at 1‐year compared with trabeculectomy (low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Adverse effects: Clinically important general adverse effect (EPSEs requiring medication ‐ medium term) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect (EPSEs… compared with perphenazine (very low certainty).

1 finding from 1 review