Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,163 questions · 1,209 findings · 133 reviews · Headline outcomes only

No studies found 176 · 14.6%GRADE not reported 47 · 3.9%Very low 241 · 19.9%Low 323 · 26.7%Moderate 315 · 26.1%High 107 · 8.9%

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs beclomethasone

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

Effects of different inhaled corticosteroids on growth in children… may leads to higher linear growth velocity (cm/year) compared with beclomethasone (low certainty).

1 finding from 1 review

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

It is very uncertain whether effects of different inhaled corticosteroids on growth in children… changes linear growth velocity (cm/year) compared with budesonide (very low certainty).

1 finding from 1 review

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Change in height · children up to 18 years of age with persistent asthma

Effects of different inhaled corticosteroids on growth in children… probably leads to higher change in height (cm) over a period of time compared with budesonide (moderate certainty).

1 finding from 1 review

Tacrolimus 0.03% vs corticosteroids

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

4 findings from 1 review
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Strategies to increase use of antenatal corticosteroids vs usual care

Perinatal mortality · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher perinatal death (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Neonatal death (death within the first 28 days of life) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Stillbirth · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher stillbirth (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Appropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher appropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Inappropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher inappropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal infection or inflammation (at population level) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher maternal infection or inflammation (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal death · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Any COPD exacerbation that requires short‐burst oral corticosteroids or antibiotics, or both · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes any COPD exacerbation that requires short‐burst oral corticosteroids… compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Intervention not reported

Patients with ≥ 1 exacerbations requiring oral corticosteroids Duration of trials: 6 to 16 weeks · adults and adolescents with persistent asthma

The intervention probably leads to lower patients with ≥ 1 exacerbations requiring oral corticosteroids… (moderate certainty).

1 finding from 1 review

Intervention not reported

Participants with ≥ 1 exacerbation requiring oral corticosteroids Duration of trials: 8 to 24 weeks · adults and adolescents with persistent asthma

The intervention showed no clear difference in participants with ≥ 1 exacerbation requiring oral corticosteroids… (low certainty).

1 finding from 1 review

Intervention not reported

Patients with ≥ 1 exacerbation requiring oral corticosteroids Duration of trials: 8 to 13 weeks · adults and adolescents with persistent asthma

The intervention showed no clear difference in patients with ≥ 1 exacerbation requiring oral corticosteroids… (moderate certainty).

1 finding from 1 review