Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

948 questions · 998 findings · 100 reviews · Headline outcomes only

No studies found 233 · 23.3%GRADE not reported 40 · 4%Very low 203 · 20.3%Low 271 · 27.2%Moderate 176 · 17.6%High 75 · 7.5%

Vitamin E + vitamin C vs placebo

Any adverse effects of vitamin supplementation sufficient to stop supplementation · pregnant women

Vitamin C and vitamin E showed no clear difference in any adverse effects of vitamin supplementation sufficient to stop… compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin D given to infants vs vitamin D given to lactating mothers

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants showed no clear difference in adverse effect (hypercalcaemia) compared with vitamin D given to lactating mothers (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention probably leads to lower all‐cause mortality in trials using vitamin D3 (cholecalciferol) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention showed no clear difference in cardiovascular mortality in trials using vitamin D3… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention probably leads to lower cancer mortality in trials using vitamin D3 (cholecalciferol) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: nephrolithiasis in trials using vitamin D3 combined with calcium ( · adults

The intervention probably leads to higher adverse events: nephrolithiasis in trials using vitamin D3 combined… (moderate certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Vitamin A deficiency · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of… compared with control (high certainty).

2 findings from 1 review

Multivitamin plus iron plus folate vs iron plus folate

Total fetal loss (including miscarriages or combined miscarriages and stillbirths) · pregnant women

Multivitamin plus iron plus folate showed no clear difference in total fetal loss (including miscarriages or combined miscarriages… compared with iron plus folate (high certainty).

1 finding from 1 review

Staple foods fortified with vitamin A vs same unfortified staple foods

Subclinical vitamin A deficiency (serum/plasma retinol 70 μmol/L or less) · general population over 2 years of age

It is very uncertain whether staple foods fortified with vitamin A changes subclinical vitamin A deficiency (serum/plasma retinol 70 μmol/L or… compared with same unfortified staple foods (very low certainty).

1 finding from 1 review

Staple foods fortified with vitamin A vs same unfortified staple foods

Clinical vitamin A deficiency (as defined by night blindness) · general population over 2 years of age

It is very uncertain whether staple foods fortified with vitamin A changes clinical vitamin A deficiency (defined as night blindness) compared with same unfortified staple foods (very low certainty).

1 finding from 1 review