Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

331 questions · 353 findings · 56 reviews

No studies found 41 · 11.6%GRADE not reported 74 · 21%Very low 128 · 36.3%Low 66 · 18.7%Moderate 32 · 9.1%High 12 · 3.4%

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

2 findings from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Mother self-reported oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Mother plaque (sub- and supragingival calculus) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Dietary advice on how to achieve a healthy diet for infants… showed no clear difference in mother plaque (sub- and supragingival calculus) compared with standard care; GRADE not reported.

1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Mother gingival health (mild or moderate bone loss) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Dietary advice on how to achieve a healthy diet for infants… showed no clear difference in mother gingival health (mild or moderate bone loss) compared with standard care; GRADE not reported.

1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether dietary advice on how to achieve a healthy diet for infants… changes caries presence in primary teeth compared with standard care (very low certainty).

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review

Tailored interventions based on sputum eosinophils vs tailored interventions based on clinical symptoms

Exacerbations · people with asthma

Tailored interventions based on sputum eosinophils probably leads to lower number of participants who had one or more exacerbations over the… compared with tailored interventions based on clinical symptoms (moderate certainty).

1 finding from 1 review

Tailored interventions based on sputum eosinophils vs tailored interventions based on clinical symptoms

Hospital admissions · people with asthma

Tailored interventions based on sputum eosinophils probably leads to lower hospitalisations compared with tailored interventions based on clinical symptoms (moderate certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs placebo (water pack)

Maternal views and experiences with treatment ‐ Would repeat treatment in future childbirth · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes maternal views and experiences with treatment ‐ Would repeat… compared with placebo (water pack) (very low certainty).

1 finding from 1 review

Multistranded stainless steel archwire vs Stainless steel archwire

Amount of crowding (change in mandibular crowding) at 8 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether multistranded stainless steel archwire changes amount of crowding (change in mandibular crowding) at 8 weeks compared with stainless steel archwire (very low certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Anaemia · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) probably leads to lower anaemia (defined as haemoglobin < 110 g/L for children aged 24‐59… compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Xylitol lozenges (4.7 g/day) vs no treatment

Number of children with a caries increment · Children (permanent teeth; baseline 8 to 10 years)

Xylitol lozenges (4.7 g/day) showed no clear difference in number of children with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review