Findings

What do systematic reviews say?

134 questions · 134 findings · 11 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 31 · 23.1%GRADE not reported 10 · 7.5%Very low 23 · 17.2%Low 34 · 25.4%Moderate 36 · 26.9%High 0 · 0%

Relaxation vs no treatment

Physical health: Reduction of bleedings, factor replacement, pain · adults and children with hemophilia

1 finding from 1 review

Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 7 participants
Very low

Summary of findings for combination antimicrobial susceptibility testing vs conventional treatment (separate testing)

Sputum bacterial density (CFU/mL) · adults and children with pulmonary exacerbation due to Pseudomonas aeruginosa

The review found no eligible studies for this question.

1 finding from 1 review

Combination antimicrobial susceptibility testing for acute exacerbations in chronic infection of Pseudomonas… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ nebulisers for delivering colistin: conventional systems vs AAD

Participant satisfaction or preference · adults and children with cystic fibrosis

Summary of findings ‐ nebulisers for delivering colistin:… may leads to lower participant satisfaction or preference compared with AAD (low certainty).

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
RR 0.45 [0.35, 0.57]
1 study · 259 participants
Low

Summary of findings ‐ nebulisers for delivering tobramycin: conventional systems vs VMT

Participant satisfaction or preference · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ nebulisers for delivering tobramycin: conventional systems vs VMT and AAD

Participant satisfaction or preference · children aged 6 ‐ 18 with cystic fibrosis

It is very uncertain whether summary of findings ‐ nebulisers for delivering tobramycin:… changes participant satisfaction or preference Satisfaction scale compared with VMT and AAD (very low certainty).

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
MD 2.7 [1.35, 4.05]
1 study · 22 participants
Very low

Summary of findings ‐ nebulisers for delivering tobramycin: conventional systems vs AAD

Participant satisfaction or preference · adults and children with cystic fibrosis

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
Very low

Summary of findings ‐ nebulisers for delivering dornase alfa conventional system vs AAD

Participant satisfaction or preference · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ nebulisers for delivering dornase alfa conventional system vs VMT

Participant satisfaction or preference · adults and children with cystic fibrosis

Summary of findings ‐ nebulisers for delivering dornase alfa:… may leads to lower participant satisfaction or preference: compared with VMT (low certainty).

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
RR 0.48 [0.31, 0.76]
1 study · 68 participants
Low

Summary of findings for nasal irrigation with topical steroids plus sinus surgery vs nasal irrigation with topical steroids alone

Eradication of bacterial infection · children and adults diagnosed with cystic fibrosis and chronic rhinosinusitis with nasal polyposis

1 finding from 1 review

Surgery for nasal polyposis in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Very low

Summary of findings ‐ nebulisers for delivering tobramycin: VMT and AAD tidal breathing mode (TBM) vs VMT and AAD target inhalation mode (TIM)

Participant satisfaction or preference · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs AAD

Participant satisfaction or preference · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ nebulisers for delivering other aerosolised medications: conventional systems vs nebuliser

Participant satisfaction or preference · adults and children with cystic fibrosis

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8 participants
Very low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Antibiotic‐resistant organisms isolated · children with SCD who have been receiving prophylactic penicillin for at least two years

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 400 participants
Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Requirement of other courses of antibiotics · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 0.94 [0.55, 1.61]
1 study · 400 participants
Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Compliance with treatment · children with SCD who have been receiving prophylactic penicillin for at least two years

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Deaths · children with SCD who have been receiving prophylactic penicillin for at least two years

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 400 participants
Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Nausea and vomiting · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in adverse effects: incidences of nausea and vomiting compared with continuation (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 1.99 [0.18, 22.12]
1 study · 400 participants
Low

Summary of findings ‐ nebulisers for delivering colistin and dornase alfa: VMT and AAD tidal breathing mode (TBM) vs VMT and AAD target inhalation mode (TIM)

Participant satisfaction or preference · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ nebulisers for delivering other aerosolised medications: VMT and AAD tidal breathing mode (TBM) vs VMT and AAD target inhalation mode (TIM)

Participant satisfaction or preference · adults with cystic fibrosis

1 finding from 1 review

Nebuliser systems for drug delivery in cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Very low

Summary of findings: ACBT vs CCPT

Quality of life · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Active cycle of breathing technique for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found