Findings

What do systematic reviews say?

162 questions · 167 findings · 24 reviews · Musculoskeletal

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No studies found 65 · 38.9%GRADE not reported 6 · 3.6%Very low 24 · 14.4%Low 55 · 32.9%Moderate 16 · 9.6%High 1 · 0.6%

Prefabricated foot orthoses vs shoes

Serious adverse events · children with symptomatic flat feet

The review found no eligible studies for this question.

1 finding from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prefabricated foot orthoses vs shoes

Pain(measured as proportion with pain) · children with asymptomatic flat feet

Prefabricated foot orthoses showed no clear difference in pain(measured as proportion with pain) compared with shoes (low certainty).

1 finding from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
RR 0.94 [0.76, 1.16]
Studies not reported
Low

Prefabricated foot orthoses vs shoes

Function or disability · children with asymptomatic flat feet

The review found no eligible studies for this question.

1 finding from 1 review

Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tricyclic antidepressants vs control

Pain < 1 week VAS scale 0 to 100 mm · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Tricyclic antidepressants vs control

Pain 1 to 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 482 participants
Very low

Tricyclic antidepressants vs control

Pain > 6 weeks Any pain measurement scale · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 368 participants
Very low

Tricyclic antidepressants vs control

Functional Status Health Assessment Questionnaire (HAQ) scale 0 to 3 · patients with pain management in rheumatoid arthritis

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Low

Tricyclic antidepressants vs control

Withdrawals due to adverse events · patients with pain management in rheumatoid arthritis

It is very uncertain whether tricyclic antidepressant changes number of Withdrawals due to Adverse Events patient interview compared with control (very low certainty).

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
RR 0.98 [0.59, 1.64]
6 studies · 455 participants
Very low

Tricyclic antidepressants vs control

Total number of adverse events patient interview · patients with pain management in rheumatoid arthritis

It is very uncertain whether tricyclic antidepressant changes total number of adverse events patient interview compared with control (very low certainty).

1 finding from 1 review

Antidepressants for pain management in rheumatoid arthritis 2011 · Cochrane Headline outcomes only
RR 1.83 [1.01, 3.3]
6 studies · 455 participants
Very low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Withdrawals due to adverse events · people with chronic gout

Skim milk enriched with GMP/G600 showed no clear difference in study withdrawals due to adverse events compared with skim milk, plus lactose powder (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
RR 1.27 [0.53, 3.03]
1 study · 120 participants
Low
Lifestyle interventions for chronic gout 2013 · Cochrane Headline outcomes only
RR 1.27 [0.53, 3.03]
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Joint pain reduction ‐ not reported · people with chronic gout

2 findings from 2 reviews · compare the 2 reviews

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Low
Lifestyle interventions for chronic gout 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Acute gout attacks · people with chronic gout

1 finding from 1 review

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

sUA acid reduction4 ‐ mmol/L at · people with chronic gout

1 finding from 1 review

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Global assessment of treatment success · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Total adverse eventsd · people with chronic gout

Skim milk enriched with GMP/G600 showed no clear difference in total adverse eventsd compared with skim milk, plus lactose powder (low certainty).

1 finding from 1 review

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
RR 0.97 [0.66, 1.45]
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Tophus regression · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Acute gout attack frequency Participant self report using gout flare diary · people with chronic gout

1 finding from 1 review

Lifestyle interventions for chronic gout 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Lifestyle interventions for chronic gout 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Physical function · people with chronic gout

1 finding from 1 review

Lifestyle interventions for chronic gout 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Low

Skim milk enriched with GMP/G600 vs skim milk & lactose powder

Serum urate normalisation ‐ not reported · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Lifestyle interventions for chronic gout 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found