Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, SDF had significantly higher treatment success than placebo (OR 33.62).
1 finding from 1 review
OR 33.62 [3.01, 375.92]
44 studies
GRADE not reported
Incidence of initial enamel caries / white spot lesions adjacent to bracket base (subject level, dichotomized) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Adding a fluoride mouthrinse to daily fluoride toothpaste produced a small reduction in the incidence of initial caries/white spot lesions adjacent to brackets (pooled risk difference -0.07, 95% CI -0.14 to -0.01; 5 studies, 491 subjects), but the authors judged the overall evidence inconclusive (ungraded).
1 finding from 1 review
Side effects or other adverse events · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
No adverse effects were reported in any of the seven included studies (ungraded).
1 finding from 1 review
Salivary Streptococcus mutans count and plaque index · Adults with dental caries
No meta-analysis was conducted; postbiotic lozenges were reported to reduce salivary Streptococcus mutans counts and plaque index versus placebo.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Pocket closure · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
2 findings from 1 review
Three studies evaluated the proportion of closed pockets three months after treatment (Al-Zahrani 2011; Courval 2020; Rodrigues 2023); studies used different criteria to measure this outcome. All studies reported an…
3 studies
GRADE not reported
No studies measured this outcome at 6 months (SoF row labeled 'Change in pocket depth from baseline to 6 months after initial treatment').
Studies not reported
No studies found
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Compared with other caries-management methods, SDF may increase caries arrestment at the individual level, but the pooled estimate is very imprecise (low certainty).
1 finding from 1 review
Length of hospital stay · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
The review found no eligible studies for this question.
1 finding from 1 review
Caries arrestment at the surface level · Children and adults without systemic diseases affecting dental health
SDF showed no clear advantage for caries arrestment at the surface level.
1 finding from 1 review
Patient satisfaction · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
The review found no eligible studies for this question.
1 finding from 1 review
Number of ibuprofen tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in number of ibuprofen tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Any adverse effect related to aPDT · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
1 finding from 1 review
Risk with control: 23 studies reported that no adverse effects of aPDT were observed. Number of participants (studies): 639 (24 studies). Certainty: Moderate. (24 studies reported adverse effects, with all studies…
24 studies · 639 participants
Moderate
Mother microbiological presence · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review
Joint pain at rest · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes joint pain at rest compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).
1 finding from 1 review
Quality of life · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Change in probing pocket depth (PPD) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in probing pocket depth (PPD) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
2 findings from 1 review
Swelling (mean) · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
The review found no eligible studies for this question.
3 findings from 1 review
No data available for this outcome.
0 studies
No studies found
RR 0.50 [0.10, 2.56]
1 study · 72 participants
Low
No data available for this outcome.
0 studies
No studies found
Percussion pain at 24 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in percussion pain at 24 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
2 findings from 1 review
Prevention of new caries (caries development/increment) · Preschool children (primary dentition) at risk of new caries
Limited evidence from two trials suggests SDF may help prevent new caries, but preventive efficacy was not meta-analyzed and remains uncertain (ungraded).
1 finding from 1 review
Attachment change · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in clinical attachment level (CAL) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
2 findings from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
Fluoride varnish applied before 4 years of age (biannual) showed no clear difference in fluorosis (percentage prevalence in permanent teeth) compared with placebo varnish (low certainty).
1 finding from 1 review