Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Duration of grade IV neutropenia (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in duration of grade IV neutropenia (lower values signify better… compared with antibiotics alone (low certainty).

1 finding from 1 review

Meropenem vs usual care

Serious adverse events maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes serious adverse events maximum compared with standard care (very low certainty).

1 finding from 1 review

Meropenem vs usual care

Neurological developmental impairment maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes neurological developmental impairment maximum compared with standard care (very low certainty).

1 finding from 1 review

Meropenem vs usual care

Necrotising enterocolitis maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes necrotising enterocolitis maximum compared with standard care (very low certainty).

1 finding from 1 review

Meropenem vs usual care

All‐cause mortality maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes all‐cause mortality maximum compared with standard care (very low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs placebo

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Sedation/tranquillisation: Not sedated ‐ at four hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in sedation/tranquillisation: Not sedated ‐ at four hours compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 1. Requiring supplementary medication ‐ antipsychotics · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in global state: 1. Requiring supplementary medication ‐ antipsychotics compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 2. Requiring 3 or more injections ‐ over 7 days · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE may leads to lower global state: 2. Requiring 3 or more injections ‐ over 7 days compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Clinical response: no clinically significant response in mental state · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in mental state: 1. No important improvement compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Adverse effects: Specific ‐ dystonia during 24 hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in adverse effects: Movement disorders ‐ dystonia (spasmodic postural… compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

Open surgery by transverse incision of the skin in the distal palmar crease vs open surgery

Resolution of symptoms Not measured · patients with trigger finger

The review found no eligible studies for this question.

3 findings from 1 review