Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,268 questions · 1,343 findings · 197 reviews

No studies found 317 · 23.6%GRADE not reported 189 · 14.1%Very low 356 · 26.5%Low 271 · 20.2%Moderate 173 · 12.9%High 37 · 2.8%

Zuclopenthixol dihydrochloride (Cis Z isomer) vs Zuclopenthixol (Cis Z/Trans E isomer)

Adverse effects: Clinically important general adverse effect (no data) · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride (Cis Z isomer) changes adverse effects: Clinically important general adverse effect compared with zuclopenthixol (Cis Z/Trans E isomer) (very low certainty).

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Stability of anterior open bite correction (1 year after treatment) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Failure to correct the anterior open bite (open bite not closed) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

Frankel's function regulator-4 (FR-4) with lip-seal training led to lower failure to correct the anterior open bite (open bite not closed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Duration of grade IV neutropenia (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in duration of grade IV neutropenia (lower values signify better… compared with antibiotics alone (low certainty).

1 finding from 1 review

Repelling-magnet splints vs Bite-blocks

Anterior open bite correction · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    About 4 months (treatment interrupted early)
    Could not be analysed statistically. After 4 months the open bite was observed to close in the magnet group, but in four out of these ten patients transverse problems (unilateral crossbite) were observed, which led to…
    1 study
    GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Failure to correct the anterior open bite (open bite not closed) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

Removable appliance with palatal crib associated with high-pull… led to lower failure to correct the anterior open bite (open bite not closed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

Complication at augmented site · Patients undergoing lateral-window maxillary sinus lift

Rotary instruments to open the lateral sinus window showed no clear difference in complications at augmented site compared with piezosurgery to open the lateral sinus window; GRADE not reported.

1 finding from 1 review

Meropenem vs usual care

Serious adverse events maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes serious adverse events maximum compared with standard care (very low certainty).

1 finding from 1 review

Meropenem vs usual care

Neurological developmental impairment maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes neurological developmental impairment maximum compared with standard care (very low certainty).

1 finding from 1 review

Meropenem vs usual care

Necrotising enterocolitis maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes necrotising enterocolitis maximum compared with standard care (very low certainty).

1 finding from 1 review