Opioids vs non‐opioid analgesics
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Women being investigated for infertility
1 finding from 1 review
- no estimate extracted1 study · 91 participantsLow
Findings
What do systematic reviews say?
30 questions · 31 findings · 12 reviews · Gynaecology and Fertility
No studies found 1 · 3.2%GRADE not reported 8 · 25.8%Very low 6 · 19.4%Low 15 · 48.4%Moderate 1 · 3.2%High 0 · 0%
Primary outcome: topical local anaesthetics vs paracervical block
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Women being investigated for infertility
1 finding from 1 review
- no estimate extracted1 study · 20 participantsLow
Primary outcome: topical local anaesthetics vs non‐opioid analgesics
Adverse event ‐ pain, visual analogue scale · Women being investigated for infertility
1 finding from 1 review
- no estimate extracted1 study · 100 participantsVery low
Primary outcome: topical local anaesthetics vs placebo or no treatment
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Women being investigated for infertility
1 finding from 1 review
- no estimate extracted2 studies · 166 participantsVery low
Oral opioid analgesics vs placebo or no treatment
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Women being investigated for infertility
1 finding from 1 review
- no estimate extracted1 study · 128 participantsModerate
Oral non‐opioid analgesics vs placebo or no treatment
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Women being investigated for infertility
1 finding from 1 review
- no estimate extracted3 studies · 133 participantsLow
GnRHa depot vs GnRHa daily injection
Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction
GnRHa depot showed no clear difference in live birth/ongoing pregnancy rate per woman Delivery of one or more… compared with gnRHa daily injection (low certainty).
1 finding from 1 review
- Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes onlyOR 0.95 [0.7, 1.31]7 studies · 873 participantsLow
Anticipated low‐responders: higher vs lower dose of FSH
300/450 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure
Anticipated low responders: higher showed no clear difference in 300/450 IU vs 150 IU compared with lower dose of FSH (low certainty).
1 finding from 1 review
- Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes onlyOR 1.2 [0.78, 1.86]3 studies · 538 participantsLow
Anticipated low‐responders: higher vs lower dose of FSH
400/450 IU vs 300 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure
Anticipated low responders: higher showed no clear difference in 400/450 IU vs 300 IU compared with lower dose of FSH (low certainty).
1 finding from 1 review
- Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes onlyOR 0.77 [0.19, 3.19]1 study · 62 participantsLow
Anticipated low‐responders: higher vs lower dose of FSH
IU vs 450 IU · women undergoing IVF/ICSI who are anticipated to have a low‐response to stimulation based on one or more ORT measure
Anticipated low responders: higher showed no clear difference in IU vs 450 IU compared with lower dose of FSH (low certainty).
1 finding from 1 review
- Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes onlyOR 1.33 [0.71, 2.52]1 study · 356 participantsLow