What do systematic reviews say?

Infiltration injection local anaesthetic vs no treatment or placebo

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on postoperative anxiety
  0 studies
  No studies found

Infiltration injection local anaesthetic vs no treatment or placebo

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  2 studies · 148 participants
  Very low

Intraligamental injection local anaesthetic vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Anand 2005 used the Venham Picture Scale but, owing to the split-mouth design, postoperative anxiety could not be compared between the LA and no-treatment sides
  1 study
  GRADE not reported

Intraligamental injection local anaesthetic vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Anand 2005: no signs of postoperative soft tissue trauma, 21 children reported numbness on the LA (experimental) side; Sammons 2007: no adverse events reported
  2 studies
  GRADE not reported

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on this outcome
  0 studies
  No studies found

Intraligamental injection local anaesthetic vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes

  On regaining consciousness, up to 1 hour (1 study to 48 hours)
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  2 studies · 115 participants
  Very low

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on this outcome
  0 studies
  No studies found

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  No study reported parental satisfaction
  0 studies
  No studies found

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  The studies did not report on patient or child satisfaction
  0 studies
  No studies found

Pre-cooling of the injection site vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before LA
  Completion of dental treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Pre-cooling of the injection site vs Conventional treatment

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before LA
  pain (SEM scale); risk with conventional treatment -, risk with pre-cooling -; 160 (1 RCT); VERY LOW. Evidence is uncertain regarding the effect of pre-cooling of the injection site on pain (data presented in a form…
  1 study · 160 participants
  Very low

Pre-cooling of the injection site vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before LA
  Adverse effects: included studies did not report on this outcome
  Studies not reported
  No studies found

Pre-cooling of the injection site vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before LA
  Acceptance of LA: included studies did not report on this outcome
  Studies not reported
  No studies found

Pre-cooling of the injection site vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before LA
  Patient satisfaction: included studies did not report on this outcome
  Studies not reported
  No studies found

Pre-cooling of the injection site vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before LA
  Successful LA/painless treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Local anaesthetic infiltration (lignocaine 2%) vs Normal saline

• Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 130 participants
  Low

Counter-stimulation or distraction vs Conventional treatment

Counter-stimulation or distraction led to lower pain on injection (Wong-Baker Faces / TPPPS / FPS-R, after LA) compared with conventional treatment; GRADE not reported.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA · Kamath 2013 (WITAUL)
  MD -3.18 [-4.26, -2.10]
  1 study
  GRADE not reported

Audiovisual distraction vs Conventional treatment

Audiovisual distraction showed no clear difference in pain on injection (Wong-Baker Faces Pain Rating Scale, after… compared with conventional treatment; GRADE not reported.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA · VR box vs conventional
  MD 0.04 [-0.41, 0.48]
  1 study
  GRADE not reported

The wand (computer-controlled LA delivery system) vs Sleeper One (electronic LA delivery system)

The wand (computer-controlled LA delivery system) showed no clear difference in pain on injection (self-reported; FACES Pain Scale Revised) compared with sleeper One (electronic LA delivery system); GRADE not reported.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  During LA (injection is the intervention)
  MD 0.68 [-1.31, 2.67]
  1 study · 112 participants
  GRADE not reported

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

The review found no eligible studies for this question.

• Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
  SoF: Not measured.
  0 studies
  No studies found
• Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes
  SoF: Not measured.
  0 studies
  No studies found