Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder
Esketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).
1 finding from 1 review
OR 2.11 [1.2, 3.68]
Studies not reported
Low
Remission · adults with Major Depressive Disorder
Esketamine probably leads to higher efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (moderate certainty).
1 finding from 1 review
OR 2.74 [1.71, 4.4]
Studies not reported
Moderate
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).
1 finding from 1 review
OR 1.58 [0.92, 2.73]
Studies not reported
Moderate
Withdrawals due to adverse events · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
1 finding from 1 review
Consumption of morphine equivalents 0 to 72 hmg · adults undergoing surgery
1 finding from 1 review
Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults undergoing surgery
1 finding from 1 review
Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · adults undergoing surgery
1 finding from 1 review
Hyperalgesia(cm2) · adults undergoing surgery
1 finding from 1 review
CNS adverse events · adults undergoing surgery
1 finding from 1 review
Number of patients with postoperative nausea and vomiting (postoperative care unit) · adults undergoing surgery
1 finding from 1 review
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
1 finding from 1 review
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
1 finding from 1 review
Awareness Postoperative interview · patients with prevention of recall of events during surgery
It is very uncertain whether thiopentone and ketamine changes awareness Postoperative interview compared with benzodiazepines (diazepam, midazolam, lorazepam) (very low certainty).
1 finding from 1 review
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).
4 findings from 1 review
OR 1.08 [0.06, 19.05]
1 study · 29 participants
Very low
OR 4.88 [0.78, 30.29]
1 study · 29 participants
Very low
OR 5.33 [1.02, 27.76]
1 study · 29 participants
Very low
Show 1 more finding
Remission · adults (aged 18 years+) with depression in bipolar disorder
It is very uncertain whether memantine changes efficacy: number of participants who achieve remission ‐ at 1 week compared with placebo (very low certainty).
1 finding from 1 review
Depressive symptoms · adults (aged 18 years+) with depression in bipolar disorder
1 finding from 1 review
Acceptability ‐ total dropouts · adults (aged 18 years+) with depression in bipolar disorder
Memantine showed no clear difference in acceptability: total dropouts compared with placebo (low certainty).
1 finding from 1 review